2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione
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2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Thalidomide-OH is a ligand for E3 ligase used in PROTAC technology.

Category
Peptide Synthesis Reagents
Catalog number
BAT-006491
CAS number
5054-59-1
Molecular Formula
C13H10N2O5
Molecular Weight
274.23
2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione
IUPAC Name
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione
Synonyms
4-Hydroxy thalidomide; E3 ligase Ligand 2; Thalidomide-4-OH; 4-Hydroxy thalidomide, (+/-)-; 3-Hydroxythalidomide; 4-Hydroxy-thalidomide; α-(3-Hydroxy-phthalimido)-glutarimid; 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione; 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione
Appearance
White to off-white solid
Purity
> 95 %
Density
1.611±0.06 g/cm3 (Predicted)
Melting Point
273-282 °C
Boiling Point
568.3±45.0 °C (Predicted)
Storage
4 °C, stored under nitrogen
*In solvent : -80 °C, 6 months; -20 °C, 1 month (stored under nitrogen)
Solubility
DMSO : ≥ 36.5 mg/mL
InChI
InChI=1S/C13H10N2O5/c16-8-3-1-2-6-10(8)13(20)15(12(6)19)7-4-5-9(17)14-11(7)18/h1-3,7,16H,4-5H2,(H,14,17,18)
InChI Key
XMPJICVFSDYOEG-UHFFFAOYSA-N
Canonical SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O
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