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Application Area

3,4-Dichloro-D-β-homophenylalanine hydrochloride

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

β−Amino Acids

Catalog number

BAT-002577

CAS number

332061-66-2

Molecular Formula

C10H12Cl3NO2

Molecular Weight

284.57

Specification
Reference Reading

IUPAC Name

(3R)-3-amino-4-(3,4-dichlorophenyl)butanoic acid;hydrochloride

Synonyms

H-D-Phe(3,4-Cl2)-OH HCl; (R)-3-Amino-4-(3,4-dichlorophenyl)butanoic acid hydrochloride

Related CAS

269396-55-6 (free base)

Storage

Store at 2-8 °C

InChI

InChI=1S/C10H11Cl2NO2.ClH/c11-8-2-1-6(4-9(8)12)3-7(13)5-10(14)15;/h1-2,4,7H,3,5,13H2,(H,14,15);1H/t7-;/m1./s1

InChI Key

RNDGKTAEVJUWKK-OGFXRTJISA-N

Canonical SMILES

C1=CC(=C(C=C1CC(CC(=O)O)N)Cl)Cl.Cl

1. Paroxetine hydrochloride

David Germann, George Ma, Feixue Han, Anna Tikhomirova Profiles Drug Subst Excip Relat Methodol. 2013;38:367-406. doi: 10.1016/B978-0-12-407691-4.00008-3.

Paroxetine hydrochloride (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3S,4R)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor. Paroxetine is indicated for the treatment of depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and social anxiety disorder. The physicochemical properties, spectroscopic data (1D and 2D NMR, UV, FT-IR, MS, PXRD), stability, methods of preparation and chromatographic methods of analysis of pharmaceutical, and biological samples of paroxetine are documented in this review. Pharmacokinetics, metabolism, and pharmacological effects are also discussed.