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Our scientists have been exploring amino acid based modification strategies to provide modified amino acids to our worldwide customers quickly and efficiently.
Amino acids are the building blocks of proteins. The scale of protein drug market continues to expand each year with growing numbers of protein products. Amino acid modifications can enhance the stability and solubility of the protein drugs and bring new properties and functions, thereby regulating the biological activity of the protein. Post-translational modifications, such as acetylation, formylation, phosphorylation, sulfonation, ubiquitination, and glycosylation, are common in organisms, affecting cell signaling, differentiation, and migration.
Chemical modification of amino acids allows the development of new molecules, which provides a starting point for the development of new medical drugs such as antibiotics. Studies have shown that the new molecular structure obtained by linking a carbon atom ring to the exact center of an amino acid molecule is compatible with a wider range of chemical structures than that of the unmodified structure. Such modification will provide scientists with a whole new set of modified amino acid molecules and produce new drugs or modified proteins that can accelerate understanding of natural biochemical systems or disease treatments. In biopharmaceutical processes, the use of modified amino acids can have a positive effect on cell culture duration or productivity. The high feed concentration achievable using modified amino acids allows the reduction of feed volume in biopharmaceutical production and therefore leads to an increase in titer.
Phosphorylated amino acids are the smallest molecular model of the chemical structure of phosphorylated proteins, which can be used for the modification of DNA, nucleosides and natural products, as well as the synthesis of phosphorylated peptides. The amino acid phosphorylation services we provide include synthesis of O-phosphorylation modification, synthesis of N-phosphorylation modification, synthesis of S-phosphorylation modification, synthesis of acyl phosphorylation modification and analysis and determination of phosphorylated amino acids.
Glycosylated amino acids can be used as building blocks for the preparation of various glycoconjugates. The stepwise synthesis of glycopeptide compounds from glycosylated amino acids is highly reliable, accurate, and easily controlled. We provide amino acid N-glycosylation modification synthesis services and N-glycosylation site prediction and analysis services.
Glycosylated amino acids have the structural characteristics and chemical reaction characteristics of sugars and amino acids, and can be used as multifunctional synthetic building blocks for the construction of sugar mimetics and peptide mimetics. We have developed an efficient and suitable synthetic strategy for amino acid O-glycosylation modification, and we have reliable capabilities for O-glycosylation site analysis.
Hydroxyamino acids have various physiological activities and are widely used in biology, chemical industry and medicine. We have successfully achieved hydroxylation synthesis of hydrophobic amino acids, β-hydroxy-γ-amino acids and β-hydroxy α-amino acids by chemical synthesis methods or biological methods.
Methylated amino acids can serve as multifunctional synthetic building blocks for the construction of physiologically active natural products and peptides. We developed an efficient synthetic strategy for amino acid methylation modification to synthesize different types of α- or β-methylated amino acids and their derivatives.
As important fine organic chemical intermediates and protein building blocks, acetylated amino acids are widely used in medicine, chemical industry, food, feed, agriculture and other fields. We provide professional acetylation site analysis services and amino acid acetylation modification synthesis services to meet the different needs of customers.
Selenoamino acids mainly include selenomethionine and selenocysteine. According to the actual needs of customers, we can use biosynthesis and chemical synthesis methods to provide amino acid selenization modification synthesis and selenium amino acid analysis services.
We can help with the following amino acid modifications:
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