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Beta-defensin 1TB precursor was found in Tupaia belangeri. It has antibacterial and antifungal activity against S. aureus, S. aureus, B. subtilis, C. albicans, E. coli ML-35P (MIC=24.0 microg/ml), P. aeruginosa PA01 (MIC=12.0 microg/ml), and P. aeruginosa.