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Boc-Tyr(OtBu)-Aib-Gln(Trt)-Gly-OH

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Boc-Tyr(OtBu)-Aib-Gln(Trt)-Gly-OH is a protected tetrapeptide commonly used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the tyrosine (Tyr) residue, while the OtBu (tert-butyl) group protects its side chain hydroxyl group, preventing premature reactions during synthesis. Aib (α-aminoisobutyric acid), a residue known for promoting helical structures, is the second amino acid in the sequence. The glutamine (Gln) residue has its side chain protected by a Trt (Trityl) group. The final amino acid, glycine (Gly), has a free carboxyl group at the C-terminus, indicated by -OH, which allows for further modifications or coupling reactions. This peptide is used to incorporate tyrosine, Aib, glutamine, and glycine into peptide chains, with strategic protection to ensure controlled and efficient synthesis.

Category

Peptide Synthesis Reagents

Catalog number

BAT-016573

CAS number

2612237-79-1

Molecular Formula

C48H59N5O9

Molecular Weight

850.03

Specification

IUPAC Name

2-[[(2S)-2-[[2-methyl-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoyl]amino]propanoyl]amino]-5-oxo-5-(tritylamino)pentanoyl]amino]acetic acid

Synonyms

YXQG; N2-(2-((S)-3-(4-(tert-Butoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutaminylglycine; Boc-Tyr(tBu)-Aib-Gln(Trt)-Gly-OH

Purity

≥96%

Density

1.193±0.06 g/cm3

Boiling Point

1098.8±65.0 °C at 760 mmHg

Sequence

Boc-Tyr(OtBu)-Aib-Gln(Trt)-Gly

InChI

InChI=1S/C48H59N5O9/c1-45(2,3)61-36-26-24-32(25-27-36)30-38(51-44(60)62-46(4,5)6)42(58)53-47(7,8)43(59)50-37(41(57)49-31-40(55)56)28-29-39(54)52-48(33-18-12-9-13-19-33,34-20-14-10-15-21-34)35-22-16-11-17-23-35/h9-27,37-38H,28-31H2,1-8H3,(H,49,57)(H,50,59)(H,51,60)(H,52,54)(H,53,58)(H,55,56)/t37-,38-/m0/s1

InChI Key

WDYWECQPRRMFHS-UWXQCODUSA-N

Canonical SMILES

CC(C)(C)OC1=CC=C(C=C1)CC(C(=O)NC(C)(C)C(=O)NC(CCC(=O)NC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCC(=O)O)NC(=O)OC(C)(C)C