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Cbz-Pro-Pro-Ser(OtBu)-NH2 is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the proline (Pro) residue, preventing it from reacting during synthesis. The Pro-Pro sequence consists of two proline residues, known for their role in introducing kinks or turns in peptide chains. The side chain hydroxyl group of the serine (Ser) residue is protected by an OtBu (tert-butyl) group to prevent unwanted reactions until deprotection. The -NH2 at the C-terminus indicates a free amine group, allowing for further modifications or coupling reactions. This peptide is used to incorporate proline and serine into peptides, with specific protections to ensure controlled synthesis and functional group reactivity.
