Fmoc-Ser(OtBu)-Asp(OtBu)-Tyr(OtBu)-Ser(OtBu)-OH is a protected tetrapeptide used in peptide synthesis. The Fmoc (Fluorenylmethyloxycarbonyl) group protects the N-terminus of the first serine (Ser) residue, preventing it from participating in premature reactions. The side chains of serine (Ser), aspartic acid (Asp), and tyrosine (Tyr) residues are protected by OtBu (tert-butyl) groups, which shield the hydroxyl and carboxyl groups during the synthesis process. The final Ser residue has a free carboxyl group at the C-terminus, indicated by -OH, which allows for further coupling or modifications. This peptide is designed to incorporate serine, aspartic acid, and tyrosine into peptide chains, with the protective groups ensuring precise and efficient synthesis.