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H-Pro-Pro-Ser(OtBu)-NH2 is a protected tripeptide used in peptide synthesis. The H indicates a free N-terminus on the proline (Pro) residue, allowing for further coupling or reactions. The sequence includes two proline residues, which are known for introducing structural kinks or turns in peptide chains. The hydroxyl group of the serine (Ser) residue is protected by an OtBu (tert-butyl) group, which prevents it from reacting until selective deprotection. The -NH2 at the C-terminus denotes a free amine group, enabling additional modifications or coupling reactions. This peptide is utilized to introduce proline and serine into peptide sequences while controlling functional group reactivity through selective protection.
