N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride
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N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category
CBZ-Amino Acids
Catalog number
BAT-001463
Molecular Formula
C22H27N5O5·HCl
Molecular Weight
477.94
Synonyms
H-Arg(Z)2-NH2 HCl

N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride, a modified amino acid with diverse biochemical applications, serves as a cornerstone in various scientific endeavors. Here are the key applications presented with heightened perplexity and burstiness:

Peptide Synthesis: Positioned at the forefront of peptide synthesis, N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride acts as a stable foundation for constructing peptides. Its shielded form allows for the precise inclusion of arginine residues during peptide assembly, ensuring the generation of pure peptides for extensive research and therapeutic ventures. The gentle removal of its protective layers under mild conditions streamlines production processes, amplifying the effectiveness of peptide synthesis undertakings.

Enzyme Inhibition Studies: Within the realm of enzyme inhibition exploration, this compound plays a pivotal role in unraveling the intricacies of arginine-associated enzymes. Scientists harness N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride to devise inhibitors or analogs mimicking substrate interactions, shedding light on enzyme mechanisms and potential therapeutic avenues. By scrutinizing the impact on enzyme activity, researchers glean profound insights into the inner workings of enzymes, laying the groundwork for innovative therapeutic interventions.

Protein Function Analysis: Immersed in the realm of protein arginine modification, N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride serves as an invaluable asset for dissecting the roles of arginine residues within protein frameworks. Incorporating this compound into proteins empowers researchers to delve into the intricate relationships between arginine residues and protein function, particularly beneficial for studying protein-protein interactions and post-translational modifications. This methodology provides a comprehensive grasp of protein functionality, unveiling the intricacies of cellular processes.

Drug Development: In the pursuit of groundbreaking therapeutic agents targeting arginine-related pathways, N-ω1,N-δ-Dicarbobenzoxy-L-argininamide hydrochloride plays a crucial role in identifying potential drug candidates. By mimicking or obstructing arginine interactions, this compound facilitates the exploration of novel treatments for ailments linked to arginine metabolism or signaling. This innovative approach opens new vistas in drug development, presenting promising solutions for tackling complex medical conditions.

1. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
2. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
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