Need Assistance?

US & Canada:
+
UK: +

FAQs

Resources

Our Highlights

GMP Grade Efficient workshop for GMP production.
Optimal Prices Buying products on this site guarantees the best price!
Commercial Batches Independent GMP manufacturing suites that handle commercial batches
Prompt Delivery Warehouses in multiple cities to ensure timely delivery
Flexible Quantity Quantities available from milligrams to ton

Application Area

Z-Val-Gly-Arg-pNA acetate salt

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Z-Val-Gly-Arg-pNA is a colorimetric substrate for urokinase.

Category

Others

Catalog number

BAT-010823

CAS number

86170-43-6

Molecular Formula

C29H40N8O9

Molecular Weight

644.68

Size	Price	Stock	Quantity
10 mg	$299	In stock
100 mg	$629	In stock

Specification
Reference Reading

IUPAC Name

acetic acid;benzyl N-[(2S)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

Synonyms

L-Argininamide, N-[(phenylmethoxy)carbonyl]-L-valylglycyl-N-(4-nitrophenyl)-, monoacetate; Carbobenzoxy-valyl-glycyl-arginine-p-nitroanilide acetate; Chromozym TRY acetate; Z-Val-Gly-Arg p-nitroanilide acetate salt; N-[(Phenylmethoxy)carbonyl]-L-valylglycyl-N-(4-nitrophenyl)-L-argininamide acetate salt; Cbz-Val-Gly-Arg-pNA acetate salt; Benzyl ((S)-1-((2-(((S)-5-guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate acetate salt

Related CAS

78333-16-1 (free base) 72536-86-8 (Deleted CAS) 78333-17-2 (Deleted CAS)

Purity

95%

Sequence

Cbz-Val-Gly-Arg-pNA.CH3CO2H

Storage

Store at -20°C

InChI

InChI=1S/C27H36N8O7.C2H4O2/c1-17(2)23(34-27(39)42-16-18-7-4-3-5-8-18)25(38)31-15-22(36)33-21(9-6-14-30-26(28)29)24(37)32-19-10-12-20(13-11-19)35(40)41;1-2(3)4/h3-5,7-8,10-13,17,21,23H,6,9,14-16H2,1-2H3,(H,31,38)(H,32,37)(H,33,36)(H,34,39)(H4,28,29,30);1H3,(H,3,4)/t21-,23-;/m0./s1

InChI Key

OOVPFYDKQBSPHP-IUQUCOCYSA-N

Canonical SMILES

CC(C)C(C(=O)NCC(=O)NC(CCCN=C(N)N)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)OCC2=CC=CC=C2.CC(=O)O

1.Studies on the anticoagulant, antimetastatic and heparin-binding properties of ghilanten-related inhibitors.

Brankamp RG1, Manley GG, Blankenship DT, Bowlin TL, Cardin AD. Blood Coagul Fibrinolysis. 1991 Feb;2(1):161-6.

The purpose of this study was to investigate the structure-activity relationships of ghilanten, an anticoagulant-antimetastatic protein of the South American leech Haementeria ghilianii. Five sequence-related variants of ghilanten, termed P1-P5, were purified and were shown to potently block the active-site hydrolysis of methoxycarbonyl-D-cyclohexylglycyl-glycyl-arginine-p-nitroanilide acetate by the human blood coagulation enzyme factor Xa; inhibition was rapid and stoichiometric. The amino acid sequence of P5 revealed a consensus sequence for heparin-binding at the carboxy-terminus. A synthetic peptide homologous to this region (93P-N-G-L-K-R-D-K-L-G-C-E-Y-C-E-C-R-P-K-R-K-L-I-P-R-L-S119) bound 125I-labelled heparin maximally at physiological pH and salt concentration. When administered intravenously to mice, the peptide suppressed lung metastases although less potentially than whole ghilanten. These findings suggest that the carboxy-terminal heparin-binding region may play a role in the antimetastatic action of the inhibitor.