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H-Glu(OtBu)-Glu(OtBu)-Tyr(OtBu)-Leu-OMe is a protected tetrapeptide used in peptide synthesis. The sequence contains two glutamic acid (Glu) residues, a tyrosine (Tyr) residue, and a leucine (Leu) residue. The side chains of the glutamic acid and tyrosine residues are protected by OtBu (tert-butyl) groups, preventing their carboxyl and hydroxyl groups from reacting prematurely during the synthesis process. The N-terminus of the first glutamic acid is free, indicated by H-, and the C-terminus of the leucine residue is esterified as OMe (methyl ester), which can be used for further chemical modifications or as a temporary protection for the carboxyl group. This protected tetrapeptide is designed to facilitate the controlled and efficient incorporation of these amino acids into peptide chains.
