4-Aminomethylphenylboronic acid hydrochloride

Background and objective: As a key pharmacophore, the cyano group widely exists in a variety of biologically active compounds. Besides, nitriles are also valuable intermediates for many common functional groups. In this current work, a new synthesis strategy was developed to obtain nitriles from aldehydes. Methods: Using commercially available aldehydes as raw materials, and hydroxylamine and hydrochloride as nitrogen sources, the corresponding nitrile compounds were successfully synthesized by the one-pot method through the promotion of imidazole hydrochloride. And it was characterized by 1H NMR, 13C NMR, and mass spectrometry. Results: Various reaction conditions were applied in order to find an optimum and convenient procedure for the formation of nitriles. The highest yields (95%) were achieved using sulfolane as a solvent, and imidazole hydrochloride as a promoter. Conclusion: In conclusion, we developed a new synthetic method for nitrile compounds from aldehydes. Twenty seven examples of functionalized nitrile compounds have been synthesized in good to excellent yields. This methodology features that an environmentally benign imidazole hydrochloride replaces transition metal catalysts and oxidants required in conventional strategies to convert aldehydes into nitriles with good functional group tolerability. Further exploration of imidazole hydrochloride is ongoing in our laboratory.

The use of Alcohol-based antiseptics is efficient and approved, however it has some limitations. This paper examined the possibility of using hypochlorite water as a chlorine-based antiseptic for handwashing in public buildings and healthcare facilities. The electrolysis method was used, which produces Hypochlorous acid (HOCl) from mixing drinking water with small amounts of sodium hydroxide. Hypochlorous acid is usually produced by blood cells to surround pathogens when the skin is cut and exposed to pathogens. The methods used were based on hydrolysing drinking water at a different salt concentration (from 0 up to saline water 0.9% NaCl) under the different power supply. The results showed that 0.005-0.01% hydrochloride water can be a perfect antiseptic that can kill most bacteria and pathogenies within 12 s. In one prototype set up one litter of the prepared solution needed the only 2 g of NaCl, 12 V and 3 amps' power. However, the pH value should be maintained to be around 5-6. The results also showed that the most efficient way was to produce the solution on-site. However, if stored properly it can be used for 7-10 days after production.

A Ag3PO4/GO/UiO-66-NH2(AGU) composite photocatalyst was prepared by an ultrasonic-assisted in situ precipitation method. The optical property, structure, composition, and morphology of photocatalysts were investigated using UV-vis diffuse reflectance spectroscopy, photoluminescence spectroscopy, electrochemical impedance spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, energy-dispersive spectrometry, transmission electron microscopy, Fourier transform infrared spectroscopy, and charge flow tracking by photodeposition of Pt and PbO2 nanoparticles. In comparison with Ag3PO4 and Ag3PO4/UiO-66-NH2(AU), the AGU composite photocatalyst showed heightened photocatalytic performance for the degradation of levofloxacin hydrochloride (LVF). The AGU photocatalyst (dosage: 0.8 g/L) with 1% mass content of graphene oxide (GO), the mass ratio of Ag3PO4 and UiO-66-NH2(U66N) reached 2:1, showed the highest photodegradation rate of 94.97% for 25 mg/L LVF after 60 min of visible light irradiation at pH = 6. The formation of a heterojunction and the addition of GO synergistically promote faster separation of electron-hole pairs, retain more active substances, and enhance the performance of the photocatalyst. Furthermore, the mechanism of the Z-scheme of the AGU composite photocatalytic is proposed.