With the rapid development of biotechnology, signal peptides have shown great application potential in the fields of cosmetics and medical aesthetics. As a short-chain peptide, signal peptides play an important role in transmitting information inside and outside of cells and regulating physiological functions, particularly in promoting collagen synthesis, anti-aging, and repairing damaged skin. With its profound technical expertise and advanced manufacturing platform, BOC Sciences offers high-quality custom synthesis, manufacturing, and analytical verification services for signal peptides, providing one-stop solutions for clients in the cosmetics, medical aesthetics, and other related fields.
Signal peptides are a class of short-chain peptides composed of 20-30 amino acids. Their primary function is to guide newly synthesized proteins into the endoplasmic reticulum or other organelles and be cleaved by enzymes after completing their transport tasks. Based on their amino acid sequence and functional characteristics, signal peptides can be divided into several types, including secretory signal peptides, localization signal peptides, and functional signal peptides. In the skincare field, signal peptides can promote the synthesis of matrix proteins, especially collagen, while also potentially increasing the production of elastin, hyaluronic acid, glycosaminoglycans, and fibronectin. These peptides promote collagen synthesis by enhancing the activity of matrix cells, making the skin appear more elastic and youthful. Common signal peptides on the market include Palmitoyl Pentapeptide-3 (Matrixyl), Palmitoyl Tripeptide-1 (Matrixyl 3000), Palmitoyl Hexapeptide (Biopeptide-EL), Palmitoyl Tripeptide-5, Hexapeptide-9, and Myristoyl Pentapeptide-11.
With its deep accumulation in peptide synthesis and bioactive substances, along with advanced production technology, BOC Sciences provides high-quality, customized signal peptide solutions for the cosmetics and medical aesthetics industries. This includes full-service offerings such as design, synthesis, manufacturing, and analytical verification to meet clients' diverse needs from research and development to large-scale production.
Signal peptides can regulate cell activities, promote collagen synthesis, repair skin barriers, and offer anti-aging, antioxidant, and other benefits. These peptides achieve exceptional effects such as wrinkle reduction, whitening, moisturizing, and skin repair. Browse our list of signal peptides in skincare to assist with your skincare product research and production.
| Effect | Peptide | Mechanism |
| Anti-aging and Wrinkle Reduction | Acetyl Hexapeptide-8 | Effectively inhibits neurotransmitter release, relaxes facial expression muscles, and reduces dynamic wrinkles. |
| Palmitoyl Tripeptide-5 | Stimulates the TGF-β signaling pathway, promotes collagen synthesis, and improves skin firmness. | |
| Repair and Anti-inflammatory | Copper Tripeptide-1 | Promotes cell regeneration, accelerates wound healing, has anti-inflammatory and antioxidant effects, and significantly repairs skin. |
| Glutathione Peptide | Strong antioxidant, inhibits free radical damage, and repairs damaged cells. | |
| Whitening and Spot Reduction | Dipeptide-2 | Effectively inhibits melanin synthesis and reduces pigmentation. |
| Oligopeptide-34 | Regulates the melanin production pathway, evens skin tone, and brightens and reduces spots. | |
| Moisturizing and Barrier Repair | Oligopeptide-1 | Enhances the moisturizing ability of the stratum corneum and promotes skin barrier repair. |
| Acetyl Tetrapeptide-5 | Improves eye puffiness, reduces dark circles, and enhances moisturizing effects. |
Additionally, BOC Sciences offers professional signal peptide sequence analysis services aimed at helping researchers gain a deeper understanding of protein signal peptide sequences and their functions. Our services cover the prediction, analysis, and validation of signal peptide sequences, assisting clients in accurately identifying signal peptides related to target proteins, thus enhancing the design and optimization of protein expression systems. With advanced bioinformatics tools and databases, we provide customized analysis reports that help clients gain valuable insights in gene engineering, drug development, and molecular biology research.
De Novo peptide sequencing is a method for determining the amino acid sequence of an unknown peptide, typically conducted without a reference database. This analytical approach is commonly used for analyzing complex peptides, especially in the absence of known sequence information. It typically involves obtaining peptide fragment ion spectra through mass spectrometry (e.g., LC-MS/MS) and then using computational algorithms to deduce the complete amino acid sequence.
C-terminal amino acid sequence analysis focuses on identifying the amino acid sequence at the C-terminal (the end portion) of a peptide chain or protein. This analysis helps determine post-translational modifications of proteins (such as peptidylation) or identify translation termination sites. The method typically combines mass spectrometry, chemical degradation methods, or other analytical techniques to obtain accurate C-terminal information.
N-terminal amino acid sequence analysis focuses on determining the amino acid sequence at the N-terminal (the starting portion) of a peptide chain or protein. Common techniques include Edman degradation, mass spectrometry, and other chromatographic methods. N-terminal sequence analysis is frequently used to study protein synthesis direction, splicing variants, or post-translational modifications.
To ensure the high purity, high activity, and high stability of signal peptide products, BOC Sciences offers comprehensive and precise analytical verification services. Additionally, for the application needs in the cosmetics and medical aesthetics fields, we also provide a variety of functional testing services, including cytological tests, in vitro transdermal absorption experiments, etc.
Demand Analysis and Consultation
Peptide Synthesis Design
Synthesis and Modification
Purification and Characterization
Quality Control and Testing
Delivery and Ongoing Support
In anti-aging products, signal peptides stimulate fibroblasts to help repair damaged tissues, reduce wrinkles and fine lines. Additionally, signal peptides enhance skin barrier function and improve moisturizing effects, making the skin smoother and more delicate. In the field of medical aesthetics, signal peptides are commonly used after microneedling and laser treatments to accelerate skin repair, reduce inflammation, and enhance treatment outcomes.
Signal peptides are widely used in recombinant protein drug expression and secretion systems. By adding appropriate signal peptide sequences to recombinant proteins, they can effectively guide proteins into the endoplasmic reticulum, where they undergo proper folding and modification, thereby improving protein expression levels, secretion efficiency, and biological activity.
Signal peptides are used in vaccine development to enhance the secretion and immunogenicity of antigens. By optimizing the signal peptide sequence of antigen proteins, it promotes efficient expression of the antigen in host cells and improves the efficiency of antigen presentation in the body, thus enhancing the vaccine's immune response.
Signal peptides are widely used in the efficient expression and secretion of industrial enzymes and functional proteins. By adding suitable signal peptides to recombinant enzymes or proteins, their secretion efficiency in microbial hosts can be significantly improved, thus enhancing industrial production efficiency.
A signal peptide is a short peptide sequence located at the N-terminus of a newly synthesized polypeptide chain, typically consisting of 15 to 30 amino acids. Its primary function is to guide the protein to specific cellular locations, such as the endoplasmic reticulum or plasma membrane. During translation, the signal peptide is recognized and binds to the signal recognition particle (SRP), initiating the directional transport of the protein.
There are generally two methods to find signal peptide sequences: one is through experimental techniques, such as N-terminal amino acid analysis; the other is through bioinformatics tools, such as SignalP, TargetP, and other prediction tools. These tools identify potential signal peptide sequences based on the known characteristics of signal peptides.
The role of signal peptides is to direct newly synthesized proteins to specific cellular structures or the extracellular environment. By binding to the signal recognition particle (SRP), signal peptides ensure that proteins are correctly directed to the endoplasmic reticulum or other target membrane systems.
The function of a signal peptide is to assist in the correct localization of a protein to a specific intracellular location or extracellular space during its synthesis. By recognizing and binding to the signal recognition particle, it ensures the directional transport of the protein, and is typically cleaved after protein synthesis, completing its guiding role.
