Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2
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Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2

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Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme degrades extracellular matrix components and may promote the spread of tumor cells. High levels of active cathepsin D were found in senile plaques in the brains of Alzheimer's patients.

Category
Others
Catalog number
BAT-014426
CAS number
400716-78-1
Molecular Formula
C104H146N24O23S
Molecular Weight
2132.52
IUPAC Name
N2-N2-(L-glutamyl)-N2-(2-((5-sulfonaphthalen-1-yl)amino)ethyl)-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N2-acetyl-N6-(4-((E)-(4-(dimethylamino)phenyl)diazenyl)benzoyl)-L-lysyl-L-glutamine
Synonyms
L-α-Glutamine, N-acetyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl-; N-Acetyl-L-α-glutamyl-N-{2-[(5-sulfo-1-naphthyl)amino]ethyl}-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-(4-{[4-(dimethylamino)phenyl]diazenyl}benzoyl)-L-lysyl-L-α-glutamine
Appearance
Red Powder
Purity
≥95%
Density
1.4±0.1 g/cm3
Sequence
Ac-ED(edans)KPILFFRLGK(dabcyl)E-NH2
Storage
Store at -20°C
Solubility
Soluble in DMSO, Ethanol, Water
InChI
InChI=1S/C104H146N24O23S/c1-10-63(6)90(124-101(146)84-35-24-54-128(84)103(148)78(32-17-19-49-105)118-100(145)83(122-96(141)77(114-64(7)129)46-48-89(134)135)59-86(130)110-53-52-109-73-33-21-30-72-71(73)29-22-36-85(72)152(149,150)151)102(147)123-80(56-62(4)5)97(142)120-82(58-66-27-15-12-16-28-66)99(144)121-81(57-65-25-13-11-14-26-65)98(143)117-76(34-23-51-112-104(107)108)95(140)119-79(55-61(2)3)93(138)113-60-87(131)115-75(94(139)116-74(91(106)136)45-47-88(132)133)31-18-20-50-111-92(137)67-37-39-68(40-38-67)125-126-69-41-43-70(44-42-69)127(8)9/h11-16,21-22,25-30,33,36-44,61-63,74-84,90,109H,10,17-20,23-24,31-32,34-35,45-60,105H2,1-9H3,(H2,106,136)(H,110,130)(H,111,137)(H,113,138)(H,114,129)(H,115,131)(H,116,139)(H,117,143)(H,118,145)(H,119,140)(H,120,142)(H,121,144)(H,122,141)(H,123,147)(H,124,146)(H,132,133)(H,134,135)(H4,107,108,112)(H,149,150,151)/b126-125+/t63-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,90-/m0/s1
InChI Key
JMMXTBIZFWHZNK-INOCCKAKSA-N
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