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Ac-Ile-Glu-Pro-Asp-AMC

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Ac-Ile-Glu-Pro-Asp-AMC is a preferred substrate sequence of granzyme B, which is a mammalian serine protease involved in the induction of rapid target cell death by cytotoxic lymphocytes.

Category

Others

Catalog number

BAT-015136

CAS number

216757-33-4

Molecular Formula

C32H41N5O11

Molecular Weight

671.69

Specification

IUPAC Name

(4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-5-[(2S)-2-[[(2S)-3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid

Synonyms

Ac-IEPD-AMC; L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; N-Acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine; N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin

Appearance

Slightly Yellow Lyophilized Powder

Purity

95%

Density

1.366±0.06 g/cm3 (Predicted)

Boiling Point

1116.0±65.0°C (Predicted)

Storage

Store at -20°C

Solubility

Soluble in DMF, DMSO, Methanol

InChI

InChI=1S/C32H41N5O11/c1-5-16(2)28(33-18(4)38)31(46)35-21(10-11-25(39)40)32(47)37-12-6-7-23(37)30(45)36-22(15-26(41)42)29(44)34-19-8-9-20-17(3)13-27(43)48-24(20)14-19/h8-9,13-14,16,21-23,28H,5-7,10-12,15H2,1-4H3,(H,33,38)(H,34,44)(H,35,46)(H,36,45)(H,39,40)(H,41,42)/t16-,21-,22-,23-,28-/m0/s1

InChI Key

XDMHHBKPMUGLEA-MNTOYCOOSA-N

Canonical SMILES

CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NC(CC(=O)O)C(=O)NC2=CC3=C(C=C2)C(=CC(=O)O3)C)NC(=O)C