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Acetyl Hexapeptide-49

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Acetyl Hexapeptide-49 is a photoprotectic cosmetic peptide which diminishes Proteinase-Activated Rece ptor 2 (PAR-2)-induced release of pro-inflammatory mediators, attenuating neurogenic inflammation and itch response in sensitive skin. It is recognized for its potential anti-aging and neurocosmetic properties. It works by inhibiting neurotransmitter release that causes muscle contractions, thereby reducing the appearance of wrinkles and fine lines. This peptide helps relax facial muscles, promoting a smoother and more youthful complexion. Additionally, it stimulates collagen synthesis, improves skin hydration, provides brightening effect, and has anti-inflammatory, freckle and acne-removing properties.

Category

Cosmetic Peptides

Catalog number

BAT-016726

CAS number

1969409-70-8

Molecular Formula

C51H57N9O8

Molecular Weight

924.07

Specification

IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoic acid

Synonyms

Acetyl Hexapeptide 49; Ac-Phe-Phe-Trp-Phe-His-Val-OH; Ac-FFWFHV; Acetyl-FFWFHV-OH; N-Acetyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-phenylalanyl-L-histidyl-L-valine; Specped AH49P

Appearance

White powder

Purity

≥95%

Sequence

Ac-Phe-Phe-Trp-Phe-His-Val

Storage

Store at -20 °C

InChI

InChI=1S/C51H57N9O8/c1-31(2)45(51(67)68)60-50(66)44(27-37-29-52-30-54-37)59-48(64)42(25-35-19-11-6-12-20-35)57-49(65)43(26-36-28-53-39-22-14-13-21-38(36)39)58-47(63)41(24-34-17-9-5-10-18-34)56-46(62)40(55-32(3)61)23-33-15-7-4-8-16-33/h4-22,28-31,40-45,53H,23-27H2,1-3H3,(H,52,54)(H,55,61)(H,56,62)(H,57,65)(H,58,63)(H,59,64)(H,60,66)(H,67,68)/t40-,41-,42-,43-,44-,45-/m0/s1

InChI Key

HZKWUUZWBZRTOO-RCWIFLETSA-N

Canonical SMILES

CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H](CC6=CC=CC=C6)NC(=O)C