Angiotensin I/II (1-7)
Need Assistance?
  • US & Canada:
    +
  • UK: +

Angiotensin I/II (1-7)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor, inducing vasorelaxation through release of NO and prostaglandins.

Category
Peptide Inhibitors
Catalog number
BAT-010238
CAS number
51833-78-4
Molecular Formula
C41H62N12O11
Molecular Weight
899
Angiotensin I/II (1-7)
IUPAC Name
(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid
Synonyms
Angiotensin II (1-7) heptapeptide; TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17)H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH;
Appearance
Powder
Purity
≥90%
Density
1.47±0.1 g/cm3(Predicted)
Sequence
DRVYIHP
Storage
Store at -20°C
Solubility
Soluble in DMSO
InChI
1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-
InChI Key
PVHLMTREZMEJCG-GDTLVBQBSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
1.Perindoprilat changes ANG (1-9) production in renal arteries isolated from young spontaneously hypertensive rats after ANG I incubation.
Wołkow PP1, Bujak-Giżycka B, Jawień J, Olszanecki R, Madej J, Rutowski J, Korbut R. Physiol Res. 2016 Mar 15. [Epub ahead of print]
We used mass spectrometry to quantitate production of angiotensinogen metabolites in renal artery of 3 and 7 months old Wistar-Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR). Tissue fragments were incubated for 15 minutes in oxygenated buffer, with added Angiotensin I. Concentrations of Angiotensins I (ANG I), II (ANG II), III (ANG III), IV (ANG IV), Angiotensin (1-9) [ANG (1-9)], Angiotensin (1-7) [ANG (1-7)], and Angiotensin (1-5) [ANG (1-5)], excreted into the buffer during experiment, were measured using liquid chromatography - mass spectrometry (LC/MS) and expressed per mg of dry tissue. Effects of pretreatment with 10 microM perindoprilat on the production of ANG I metabolites were quantitated. Background production of any of ANG I metabolites differed neither between WKY and SHR rats nor between 3 and 7 months old rats. Perindoprilat pretreatment of renal arteries resulted, as expected, in decrease of ANG II production. However, renal arteries of 7-month-old SHR rats were resistant to ACE inhibitor and did not change ANG II production in response to perindoprilat.
2.Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways.
Xiao X1, Zhang C1, Ma X2, Miao H3, Wang J1, Liu L1, Chen S1, Zeng R3, Chen Y4, Bihl JC5. Exp Cell Res. 2015 Aug 1;336(1):58-65. doi: 10.1016/j.yexcr.2015.06.010. Epub 2015 Jun 19.
Angiotensin (Ang) II, the main effector of the renin-angiotensin system, has been implicated in the pathogenesis of vascular diseases. Ang-(1-7) binds to the G protein-coupled Mas receptor (MasR) and can exert vasoprotective effects. We investigated the effects and underlying mechanisms of Ang-(1-7) on Ang II-induced dysfunction and oxidative stress in human brain microvascular endothelial cells (HbmECs). The pro-apoptotic activity, reactive oxygen species (ROS) and nitric oxide (NO) productions in HbmECs were measured. The protein expressions of nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2), serine/threonine kinase (Akt), endothelial nitric oxide synthase (eNOS) and their phosphorylated forms (p-Akt and p-eNOS) were examined by western blot. MasR antagonist and phosphatidylinositol-3-kinase (PI3K) inhibitor were used for receptor/pathway verification. We found that Ang-(1-7) suppressed Ang II-induced pro-apoptotic activity, ROS over-production and NO reduction in HbmECs, which were abolished by MasR antagonist.
3.Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling.
Jin HY1,2, Chen LJ3,4, Zhang ZZ5,6, Xu YL7, Song B8, Xu R9, Oudit GY10, Gao PJ11,12, Zhu DL13,14,15, Zhong JC16,17,18. J Transl Med. 2015 Aug 6;13:255. doi: 10.1186/s12967-015-0616-8.
BACKGROUND: The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apolipoprotein E (ApoE) knockout (KO) kidneys.
4.Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin.
Ribeiro AA1, Palomino Z1, Lima MP2, Souza LE3, Ferreira DS4, Pesquero JB4, Irigoyen MC3, Pesquero JL5, Casarini DE6. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):947-55. doi: 10.1177/1470320315595572. Epub 2015 Jul 27.
INTRODUCTION: Tonin is an enzyme that is able to generate angiotensin II (Ang II) from angiotensin I (Ang I) or directly from angiotensinogen. Our goal was to characterize the renal renin-angiotensin system in transgenic mice that express rat tonin (TGM`(rTon)).
Online Inquiry
Verification code
Inquiry Basket