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Apelin-12 (human, bovine, mouse, rat)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Apelin-12 (human, bovine, mouse, rat), an endogenous ligand of the human orphan receptor APJ, lowers arterial blood pressure without altering heart rate in anesthetized rats. Its vasoactive effect may be related to the activation of endothelial nitric oxide synthase.

Category

Peptide Inhibitors

Catalog number

BAT-015270

CAS number

229961-08-4

Molecular Formula

C64H103N21O14S

Molecular Weight

1422.72

Specification

IUPAC Name

(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

Synonyms

Preproapelin (66-77) (human, bovine, mouse, rat); H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine; (Des-Gln1)-Apelin-13 (human, bovine, mouse, rat); Apelin Precursor (66-77) (human, bovine, mouse, rat); N5-(Diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine

Appearance

White Lyophilized Powder

Purity

≥95% by HPLC

Density

1.5±0.1 g/cm3

Sequence

RPRLSHKGPMPF

Storage

Store at -20°C

Solubility

Soluble in Water

InChI

InChI=1S/C64H103N21O14S/c1-37(2)30-44(79-53(89)42(18-10-25-73-64(69)70)77-58(94)49-20-12-27-84(49)60(96)40(66)16-9-24-72-63(67)68)54(90)82-47(35-86)56(92)80-45(32-39-33-71-36-75-39)55(91)76-41(17-7-8-23-65)52(88)74-34-51(87)83-26-11-19-48(83)57(93)78-43(22-29-100-3)61(97)85-28-13-21-50(85)59(95)81-46(62(98)99)31-38-14-5-4-6-15-38/h4-6,14-15,33,36-37,40-50,86H,7-13,16-32,34-35,65-66H2,1-3H3,(H,71,75)(H,74,88)(H,76,91)(H,77,94)(H,78,93)(H,79,89)(H,80,92)(H,81,95)(H,82,90)(H,98,99)(H4,67,68,72)(H4,69,70,73)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1

InChI Key

KIODTAJAFBDDGP-TZIGXLGFSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)N