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Brevinin-2Eg

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Brevinin-2Eg is an antimicrobial peptide found in Rana ridibunda (Pelophylax ridibundus, Marsh frog). It has antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and shows hemolytic activity.

Category

Functional Peptides

Catalog number

BAT-012961

Molecular Formula

C142H245N43O45S3

Molecular Weight

3370.96

Specification
Reference Reading

IUPAC Name

(4R,7S,13S,16S,19S,22R)-22-((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,35S,41S,44S,47S,50S,53S,56S,59S,62S,65S,68S,71S,74S)-8-((1H-imidazol-4-yl)methyl)-77-amino-11,56-bis(2-amino-2-oxoethyl)-23-(3-amino-3-oxopropyl)-35,47,59-tris(4-aminobutyl)-74-((S)-sec-butyl)-68-(carboxymethyl)-44,65-bis((R)-1-hydroxyethyl)-2,20-bis(hydroxymethyl)-14,17,26,53,62-pentaisobutyl-5,29,41,50-tetramethyl-71-(2-(methylthio)ethyl)-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-pentacosaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75-pentacosaazaheptaheptacontanamido)-7-(3-amino-3-oxopropyl)-19-(4-aminobutyl)-13-(hydroxymethyl)-16-isobutyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosane-4-carboxylic acid

Synonyms

Gly-Ile-Met-Asp-Thr-Leu-Lys-Asn-Leu-Ala-Lys-Thr-Ala-Gly-Lys-Gly-Ala-Leu-Gln-Ser-Leu-Leu-Asn-His-Ala-Ser-Cys-Lys-Leu-Ser-Gly-Gln-Cys (Disulfide bridge: Cys27-Cys33)

Appearance

Lyophilized Powder or Liquid

Purity

≥97%

Sequence

GIMDTLKNLAKTAGKGALQSLLNHASCKLSGQC (Disulfide bridge: Cys27-Cys33)

Storage

Store at -20°C

1. Antimicrobial peptides of the brevinin-2 family isolated from gastric tissue of the frog, Rana esculenta

Y Wang, F C Knoop, I Remy-Jouet, C Delarue, H Vaudry, J M Conlon Biochem Biophys Res Commun. 1998 Dec 30;253(3):600-3. doi: 10.1006/bbrc.1998.9822.

Four structurally related peptides with potent growth-inhibitory activity towards Escherichia coli were isolated from an extract of the stomach of the European green frog Rana esculenta, and were identified as members of the brevinin-2 family. Two peptides, termed brevinin-2Eg (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCK LS30GQC) and brevinin-2Eh (GIMDTLKNLA10 KTAGKGALQS20 LLNHASCKL S30 KQC) have not been described previously. One peptide is identical to brevinin-2Ec, previously isolated from R. esculenta skin secretions, and one peptide is identical to brevinin-2Ef whose structure has been deduced from a cloned cDNA prepared from a R. esculenta skin cDNA library. The data demonstrate that certain peptides of the brevinin-2 family, like the magainins in the toad, Xenopus laevis, may play an important role in protecting the gastrointestinal tract of Ranid frogs against microbial invasion.

2. [Expressions of differential proteins in the expressed prostatic secretion of patients with III A chronic prostatitis]

Xiao-Fan Dai, Kai-Min Guo, Cong-Qi Du, Ling-Yun Liu, Fu-Biao Li, Hong-Liang Wang Zhonghua Nan Ke Xue. 2013 Sep;19(9):780-4.

Objective: To study the expressions of differential proteins in the expressed prostatic secretion (EPS) of patients with III A chronic prostatitis and healthy men. Methods: We collected EPS samples from 35 patients with III A chronic prostatitis and 18 age-matched healthy men, and detected the differentially expressed proteins in EPS by MALDI-TOF/MS. Based on the data obtained, we conducted a statistical analysis on the mass-to-charge (m/z) ratios of different proteins and a retrieval analysis on the relevant proteins using the protein database. Results: In the comparative studies of the III A chronic prostatitis patients and healthy men, 5 proteins were detected as at least 2-fold differentially expressed, which were probably brevinin-2Eg, big endothelin-1, alpha-defensin 15, beta-defensin 134 and prostatic steroid-binding protein C2. The m/z ratios were significantly up-regulated in 3 372, 3 487, 425 and 5 325 Da proteins (P < 0.01) and down-regulated in 10631Da (P < 0.01). Conclusion: Proteins are differentially expressed in the EPS of III A chronic prostatitis patients and healthy men, and these proteins may be significantly correlated with the development and progression of III A chronic prostatitis.