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BVD 10

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

BVD 10 is a selective NPY Y1 receptor antagonist (Ki = 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors, respectively) with no activity at Y4 receptors.

Category
Peptide Inhibitors
Catalog number
BAT-010333
CAS number
262418-00-8
Molecular Formula
C58H92N16O13
Molecular Weight
1221.46
BVD 10
IUPAC Name
methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoate
Synonyms
BVD 10; BVD10; BVD-10
Appearance
White Lyophilized Solid
Purity
>98%
Density
1.39±0.1 g/cm3(Predicted)
Sequence
INPIYRLRY(Modifications: Tyr-9 = Tyr-OMe)
Storage
Store at -20°C
Solubility
Soluble in DMSO
InChI
InChI=1S/C58H92N16O13/c1-8-32(5)46(60)53(83)71-42(30-45(59)77)55(85)74-26-12-15-44(74)52(82)73-47(33(6)9-2)54(84)70-41(28-34-16-20-36(75)21-17-34)51(81)68-38(13-10-24-65-57(61)62)48(78)69-40(27-31(3)4)50(80)67-39(14-11-25-66-58(63)64)49(79)72-43(56(86)87-7)29-35-18-22-37(76)23-19-35/h16-23,31-33,38-44,46-47,75-76H,8-15,24-30,60H2,1-7H3,(H2,59,77)(H,67,80)(H,68,81)(H,69,78)(H,70,84)(H,71,83)(H,72,79)(H,73,82)(H4,61,62,65)(H4,63,64,66)/t32-,33-,38-,39-,40-,41-,42-,43-,44-,46-,47-/m0/s1
InChI Key
JLQHEFJKMUJISI-QUCBMPEKSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(CC(=O)N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)OC)N
1.Seroprevalence study of the main causes of abortion in dairy cattle in Morocco.
Lucchese L1, Benkirane A, Hakimi I, El Idrissi A, Natale A. Vet Ital. 2016 Mar 31;52(1):13-9. doi: 10.12834/VetIt.388.1813.1.
Sera from 221 cattle were collected in 25 farms in Morocco to investigate the evidence and circulation of some of the main bovine abortive agents in the dairy cattle farming, where abortions are often reported. All sera were examined for brucellosis, 176 for neosporosis, 88 for leptospirosis, and 42 for Bovine viral diarrhoea (BVD/MD), Bovine Herpesvirus 1 (BHV-1) (Infectious bovine rhinotracheitis, IBR/IPV), and Bovine Herpesvirus 4 (BHV-4) infections (at least 1 sample per herd). Abortions were reported in 23 (10.4%) of the 221 tested cattle. Antibodies against the investigated pathogens were detected in all samples tested, with an overall seroprevalence of 33.48% for Brucella, 9.09% for Leptospira, 8.52% for Neospora, 37.71% for BVDV, 50% for BHV-1, 9.52% for BHV-4. As for Leptospira antibodies against serovars Hardjo, Pomona, and Tarassovi were identi ed. Mixed infections were common. The lack of evidence of non-infectious factors epidemiologically related to abortions suggested that the investigated agents are to be considered important risk factors in the dynamic of the abortion syndrome, even if further investigations are necessary to identify the abortion cause.
2.Nucleus ^{26}O: A Barely Unbound System beyond the Drip Line.
Kondo Y1, Nakamura T1, Tanaka R1, Minakata R1, Ogoshi S1, Orr NA2, Achouri NL2, Aumann T3,4, Baba H5, Delaunay F2, Doornenbal P5, Fukuda N5, Gibelin J2, Hwang JW6, Inabe N5, Isobe T5, Kameda D5, Kanno D1, Kim S6, Kobayashi N1, Kobayashi T7, Kubo T5, Leblond S2, Lee J5, Marqués FM2, Motobayashi T5, Murai D8, Murakami T9, Muto K7, Nakashima T1, Nakatsuka N9, Navin A10, Nishi S1, Otsu H5, Sato H5, Satou Y6, Shimizu Y5, Suzuki H5, Takahashi K7, Takeda H5, Takeuchi S5, Togano Y1,4, Tuff AG11, Vandebrouck M12, Yoneda K5. Phys Rev Lett. 2016 Mar 11;116(10):102503. doi: 10.1103/PhysRevLett.116.102503. Epub 2016 Mar 9.
The unbound nucleus ^{26}O has been investigated using invariant-mass spectroscopy following one-proton removal reaction from a ^{27}F beam at 201  MeV/nucleon. The decay products, ^{24}O and two neutrons, were detected in coincidence using the newly commissioned SAMURAI spectrometer at the RIKEN Radioactive Isotope Beam Factory. The ^{26}O ground-state resonance was found to lie only 18±3(stat)±4(syst)  keV above threshold. In addition, a higher lying level, which is most likely the first 2^{+} state, was observed for the first time at 1.28_{-0.08}^{+0.11}  MeV above threshold. Comparison with theoretical predictions suggests that three-nucleon forces, pf-shell intruder configurations, and the continuum are key elements to understanding the structure of the most neutron-rich oxygen isotopes beyond the drip line.
3.Microalgae from domestic wastewater facility's high rate algal pond: Lipids extraction, characterization and biodiesel production.
Drira N1, Piras A2, Rosa A3, Porcedda S2, Dhaouadi H4. Bioresour Technol. 2016 Apr;206:239-44. doi: 10.1016/j.biortech.2016.01.082. Epub 2016 Jan 30.
In this study, the harvesting of a biomass from a high rate algal pond (HRAP) of a real-scale domestic wastewater treatment facility and its potential as a biomaterial for the production of biodiesel were investigated. Increasing the medium pH to 12 induced high flocculation efficiency of up to 96% of the biomass through both sweep flocculation and charge neutralization. Lipids extracted by ultrasounds from this biomass contained around 70% of fatty acids, with palmitic and stearic acids being the most abundant. The extract obtained by supercritical CO2 contained 86% of fatty acids. Both conventional solvents extracts contained only around 10% of unsaturated fats, whereas supercritical CO2 extract contained more than 40% of unsaturated fatty acids. This same biomass was also subject to direct extractive-transesterification in a microwave reactor to produce fatty acid methyl esters, also known as, raw biodiesel.
4.Expert Opinion on the Perceived Effectiveness and Importance of On-Farm Biosecurity Measures for Cattle and Swine Farms in Switzerland.
Kuster K1, Cousin ME2, Jemmi T3, Schüpbach-Regula G1, Magouras I1. PLoS One. 2015 Dec 10;10(12):e0144533. doi: 10.1371/journal.pone.0144533. eCollection 2015.
Biosecurity is crucial for safeguarding livestock from infectious diseases. Despite the plethora of biosecurity recommendations, published scientific evidence on the effectiveness of individual biosecurity measures is limited. The objective of this study was to assess the perception of Swiss experts about the effectiveness and importance of individual on-farm biosecurity measures for cattle and swine farms (31 and 30 measures, respectively). Using a modified Delphi method, 16 Swiss livestock disease specialists (8 for each species) were interviewed. The experts were asked to rank biosecurity measures that were written on cards, by allocating a score from 0 (lowest) to 5 (highest). Experts ranked biosecurity measures based on their importance related to Swiss legislation, feasibility, as well as the effort required for implementation and the benefit of each biosecurity measure. The experts also ranked biosecurity measures based on their effectiveness in preventing an infectious agent from entering and spreading on a farm, solely based on transmission characteristics of specific pathogens.
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