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Caffeic-PH is a derivative of caffeic acid that combines with the dipeptide Pro-His. This compound has been reported to exhibit significant antioxidant properties, including free radical scavenging and lipid peroxidation inhibition activity. It is considered to be a powerful antioxidant in both hydrophilic and lipophilic systems, likely due to the structure of proline that enables histidine to effectively donate electrons. The addition of short peptides like Pro-His to caffeic acid is believed to synergistically enhance its antioxidative activity. This enhanced antioxidant activity contributes to the skin-tightening effect by protecting the skin from oxidative stress, which can lead to skin laxity and wrinkles. Therefore, CA-PH can be used as a potent dermal therapeutic agent and a useful cosmetic ingredient for skin tightening and anti-aging purposes.
