Characteristic MSH-Tetrapeptide
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Characteristic MSH-Tetrapeptide

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Category
Others
Catalog number
BAT-014921
CAS number
4289-02-5
Molecular Formula
C32H40N10O5
Molecular Weight
644.72
Characteristic MSH-Tetrapeptide
IUPAC Name
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
Synonyms
His-DPhe-Arg-Trp; ACTH (6-9)
Sequence
H-His-Phe-Arg-Trp-OH
InChI
InChI=1S/C32H40N10O5/c33-23(15-21-17-36-18-39-21)28(43)41-26(13-19-7-2-1-3-8-19)30(45)40-25(11-6-12-37-32(34)35)29(44)42-27(31(46)47)14-20-16-38-24-10-5-4-9-22(20)24/h1-5,7-10,16-18,23,25-27,38H,6,11-15,33H2,(H,36,39)(H,40,45)(H,41,43)(H,42,44)(H,46,47)(H4,34,35,37)/t23-,25-,26-,27-/m0/s1
InChI Key
CAYNQHPLZNPBIO-MNUOIFNESA-N
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)O)NC(=O)C(CC4=CN=CN4)N
1. The autophagy community
Daniel J Klionsky Autophagy. 2012 Jul 1;8(7):1003. doi: 10.4161/auto.20666. Epub 2012 May 31.
There are various definitions of community. A definition that I found in one of my dictionaries is the following: "A social, religious, occupational, or other group sharing common characteristics or interests and perceived or perceiving itself as distinct in some respect from the larger society within which it exists." Thus, I think it is fair to say that there is a worldwide autophagy community. That is, there is a group of researchers (our occupation), whose members share an interest in autophagy (our common characteristic), and that group is distinct from the larger society (I do not want to begin describing the many ways this applies). But do we feel like a community, and do we need a community? I suggest that a community is indeed beneficial, and I propose one mechanism for enhancing the development of the autophagy community.
2. Apophyllite waveplates
Nathan Hagen, Kentaro Yoshida, Yuejin Shan, Yukitoshi Otani Appl Opt. 2022 Aug 1;61(22):6518-6526. doi: 10.1364/AO.463809.
We investigate the polarization characteristics of apophyllite crystals in an attempt to evaluate their potential use for achromatic waveplates. Among the 50 plates that we extracted and polished from natural apophyllite crystals, a few show the sought-for characteristic of birefringence that increases linearly with the wavelength. However, we also find that the crystals among our samples exhibit a sectored structure in their polarization properties, as well as an undesirable degree of spatial nonuniformity.
3. Brow Bossing Reduction
Bryan Rolfes Otolaryngol Clin North Am. 2022 Aug;55(4):785-795. doi: 10.1016/j.otc.2022.04.003.
Testosterone creates several characteristic changes in the upper face. These changes include elevating and squaring the hairline, flattening the central forehead, and increasing the anterior projection of the brow bone and orbital rims. When present, these changes will give a strong masculine characteristic to the face overall. Several techniques will be described here to restore the feminine characteristics of the upper face.
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