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It is a synthetic peptide based on the sequence corresponding to residues 359 to 374 of α1-antitrypsin. C105Y can penetrate cell membrane rapidly, enter the cytoplasm, and localize to the nucleus and nucleolus of live culture cells. C105Y peptide enters the nucleolus very rapidly in an energy-dependent manner. Membrane transport and nuclear localization are energy-independent. It enhances gene expression in DNA nanoparticles.
