DL-Glutamic acid monohydrate
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DL-Glutamic acid monohydrate

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Category
DL-Amino Acids
Catalog number
BAT-003586
CAS number
19285-83-7
Molecular Formula
C5H9NO4·H2O
Molecular Weight
165.15
DL-Glutamic acid monohydrate
IUPAC Name
2-aminopentanedioic acid;hydrate
Synonyms
DL-Glu-OH H2O; (RS)-2-Aminopentanedioic acid monohydrate; 2-aminopentanedioic acid hydrate
Appearance
White to off-white crystalline powder
Purity
≥ 99% (Assay)
Melting Point
185 °C (dec.)
Boiling Point
430.7°C at 760mmHg
Storage
Store at RT
InChI
InChI=1S/C5H9NO4.H2O/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H2
InChI Key
OZDAOHVKBFBBMZ-UHFFFAOYSA-N
Canonical SMILES
C(CC(=O)O)C(C(=O)O)N.O

DL-Glutamic acid monohydrate is a crystalline form of the amino acid glutamic acid, where the DL-isomer (a mixture of both L- and D-glutamic acid) is bound with a single water molecule. It is widely used in both the food and pharmaceutical industries due to its versatile properties. As an important amino acid derivative, DL-glutamic acid serves as a precursor in the synthesis of various peptides, neurotransmitters, and other bioactive molecules. The inclusion of water in the monohydrate form contributes to its stability and ease of handling in scientific applications.

One key application of DL-Glutamic acid monohydrate is in the food industry as a flavor enhancer. It is commonly used to create monosodium glutamate (MSG), a well-known additive that enhances the savory, umami flavor in a wide range of food products. This compound plays a crucial role in improving the taste profile of processed foods, soups, sauces, and snacks. The glutamate component in DL-glutamic acid activates taste receptors on the tongue, enhancing the overall flavor experience. This application has made it a staple in the food manufacturing sector.

DL-Glutamic acid monohydrate also finds extensive use in the pharmaceutical industry. It serves as an important precursor in the synthesis of various bioactive compounds, including neurotransmitters and pharmaceutical intermediates. In particular, it is involved in the production of glutamate-based drugs, which can modulate neurotransmission processes in the central nervous system. This makes DL-glutamic acid monohydrate useful in the development of treatments for neurological disorders such as epilepsy, Alzheimer's disease, and schizophrenia, where glutamate signaling is often implicated.

Another important application of DL-Glutamic acid monohydrate is in biotechnology, where it is utilized in microbial fermentation processes. The compound acts as a nitrogen source for the growth of microorganisms, enabling the production of various biochemicals. For example, certain microorganisms can use DL-glutamic acid as a substrate to synthesize essential amino acids, vitamins, and other metabolic products. This makes DL-glutamic acid monohydrate an essential component in the fermentation-based production of high-value chemicals and biofuels.

Finally, DL-Glutamic acid monohydrate plays a role in the development of nutritional supplements. Glutamic acid, as a precursor to several important metabolites, is used to formulate dietary supplements aimed at supporting brain health, muscle recovery, and metabolic function. It is often included in formulations targeting athletic performance or cognitive enhancement, as glutamic acid is involved in processes like protein synthesis, neurotransmission, and energy metabolism. This makes it a valuable component in the growing market of health and wellness products.

1.Structure and behaviour of the free radicals generated in gamma irradiated amino acid and iminodiacetic acid derivatives.
Osmanoğlu S1, Aydın M, Osmanoğlu YE, Dicle IY, Başkan MH. Spectrochim Acta A Mol Biomol Spectrosc. 2011 May;78(5):1611-4. doi: 10.1016/j.saa.2011.02.016. Epub 2011 Feb 18.
An EPR study has been carried out to investigate the structure and behaviour of the free radical formed γ-irradiated l-alaninamide hydrochloride, dl-glutamic acid monohydrate and N-(2-carboxyethyl) iminodiacetic acid powders at room temperature. The observed paramagnetic species have been attributed to the CH(3)ĊHCONH(2), HOOCCH(2)CH(2)ĊHCOOH and HOOCCH(2)CH(2)NĊHCH(2)(COOH)(2) radicals, respectively. Some spectroscopic properties and suggestions concerning possible structure of the radicals were also discussed in this study.
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