Dynorphin A 1-10 acetate
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Dynorphin A 1-10 acetate

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Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide that binds to the extracellular loop 2 of the κ-opioid receptor. It also blocks the NMDA activation current with an IC50 of 42.0 μM.

Category
Peptide Inhibitors
Catalog number
BAT-016388
Molecular Formula
C59H95N19O14
Molecular Weight
1294.53
Dynorphin A 1-10 acetate
IUPAC Name
acetic acid;(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxylic acid
Synonyms
H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-OH.CH3CO2H; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-proline acetic acid; 1-10-Dynorphin A (swine) acetate; α-Neoendorphin (pig), 7-L-arginine-8-L-isoleucine-9-L-arginine-10-L-proline-, acetate (1:1); Porcine dynorphin A (1-10) acetate
Related CAS
79994-24-4 (free base)
Purity
≥95%
Sequence
YGGFLRRIRP.CH3CO2H
Storage
Store at -20°C
InChI
InChI=1S/C57H91N19O12.C2H4O2/c1-5-33(4)46(52(85)73-40(17-11-25-67-57(63)64)53(86)76-26-12-18-43(76)54(87)88)75-49(82)39(16-10-24-66-56(61)62)71-48(81)38(15-9-23-65-55(59)60)72-50(83)41(27-32(2)3)74-51(84)42(29-34-13-7-6-8-14-34)70-45(79)31-68-44(78)30-69-47(80)37(58)28-35-19-21-36(77)22-20-35;1-2(3)4/h6-8,13-14,19-22,32-33,37-43,46,77H,5,9-12,15-18,23-31,58H2,1-4H3,(H,68,78)(H,69,80)(H,70,79)(H,71,81)(H,72,83)(H,73,85)(H,74,84)(H,75,82)(H,87,88)(H4,59,60,65)(H4,61,62,66)(H4,63,64,67);1H3,(H,3,4)/t33-,37-,38-,39-,40-,41-,42-,43-,46-;/m0./s1
InChI Key
POASIVKFXRDCLG-LSYYUYRJSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=C(C=C3)O)N.CC(=O)O
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