Fmoc-β-alanine pentafluorophenyl ester
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Fmoc-β-alanine pentafluorophenyl ester

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Fmoc-β-alanine pentafluorophenyl ester is a Fmoc protected alanine derivative. Also, it is a reagent used in the synthesis of benzophenone-peptide nucleic acid derivative for mitochondrial targeting.

Category
Fluorinated Amino Acids
Catalog number
BAT-007587
CAS number
149303-38-8
Molecular Formula
C24H16F5NO4
Molecular Weight
477.40
Fmoc-β-alanine pentafluorophenyl ester
IUPAC Name
(2,3,4,5,6-pentafluorophenyl) 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate
Synonyms
Fmoc-β-Ala-OPfp; FMOC-BETA-ALA-OPFP; AK170195; Fmoc-b-Ala-OPfp; Fmoc-I(2)-Ala-OPfp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine-pentafluorophenylester; (2,3,4,5,6-pentafluorophenyl) 3-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate; FMOC BETA ALA OPFP
Appearance
White powder
Purity
≥ 99% (HPLC)
Melting Point
116-118 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C24H16F5NO4/c25-18-19(26)21(28)23(22(29)20(18)27)34-17(31)9-10-30-24(32)33-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,30,32)
InChI Key
HKRARRDDNQDLOY-UHFFFAOYSA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCC(=O)OC4=C(C(=C(C(=C4F)F)F)F)F

Fmoc-β-alanine pentafluorophenyl ester is a chemical reagent frequently utilized in peptide synthesis and various biotechnological applications. Here are the key applications of Fmoc-β-alanine pentafluorophenyl ester, presented with a high degree of perplexity and burstiness:

Solid-Phase Peptide Synthesis: A cornerstone in peptide synthesis, Fmoc-β-alanine pentafluorophenyl ester plays a pivotal role in solid-phase synthesis by acting as a fundamental building block. Through its interaction with amino acid residues, it facilitates the creation of peptides with meticulously crafted sequences. This method forms the bedrock for generating peptides utilized in research, diagnostics, and therapeutic endeavors.

Drug Development: At the forefront of pharmaceutical innovation, Fmoc-β-alanine pentafluorophenyl ester-derived peptides hold immense promise in drug development, particularly in the realm of peptide-based therapeutics. These synthetic peptides have the capability to mimic crucial biological molecules, aiding in the exploration and refinement of drug candidates. This methodology plays a key role in the creation of treatments for various diseases like cancer, diabetes, and infectious ailments, reshaping the landscape of modern medicine.

Bioconjugation: In the intricate world of bioconjugation, Fmoc-β-alanine pentafluorophenyl ester emerges as a vital tool for linking peptides or biomolecules to carriers or labels. This process is fundamental in crafting diagnostic tools and targeted delivery systems. By attaching biomolecules to specific carriers, researchers can amplify the efficacy of various treatments, enhancing detection, imaging, and therapeutic outcomes.

Proteomics Research: Valued in the realm of proteomics, Fmoc-β-alanine pentafluorophenyl ester is instrumental in synthesizing peptide libraries. These libraries play a pivotal role in screening protein interactions, enzyme substrates, and antibody recognition sites, shedding light on protein functions and interactions. This application is essential for developing new biomolecular assays and deepening our understanding of the complex world of proteomics.

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