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Application Area

G280-9

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

G280-9 is a natural epitope peptide containing 9 amino acids and is also a relevant target for melanoma expression.

Category

Peptide Inhibitors

Catalog number

BAT-010485

CAS number

156761-76-1

Molecular Formula

C44H67N9O14

Molecular Weight

946.05

Specification
Reference Reading

IUPAC Name

(4S)-4-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-[(2S)-2-[[2-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid

Synonyms

95 kDa Melanocyte-Specific Secreted Glycoprotein (256-264) (human, bovine, mouse); Melanocyte Lineage-Specific Antigen GP100 (256-264) (human, bovine, mouse); ME20-M/ME20-S (256-264) (human, bovine, mouse); H-Tyr-Leu-Glu-Pro-Gly-Pro-Val-Thr-Ala-OH; L-tyrosyl-L-leucyl-L-alpha-glutamyl-L-prolyl-glycyl-L-prolyl-L-valyl-L-threonyl-L-alanine; Melanocyte Protein PMEL 17 (256-264) (human, bovine, mouse)

Appearance

White or Off-white Lyophilized Powder

Purity

≥95%

Density

1.325±0.06 g/cm3 (Predicted)

Boiling Point

1379.3±65.0°C (Predicted)

Sequence

YLEPGPVTA

Storage

Store at -20°C

Solubility

Soluble in Water (≥50 mg/mL), DMSO

InChI

InChI=1S/C44H67N9O14/c1-22(2)19-30(49-37(59)28(45)20-26-11-13-27(55)14-12-26)38(60)48-29(15-16-34(57)58)43(65)53-18-8-9-31(53)39(61)46-21-33(56)52-17-7-10-32(52)40(62)50-35(23(3)4)41(63)51-36(25(6)54)42(64)47-24(5)44(66)67/h11-14,22-25,28-32,35-36,54-55H,7-10,15-21,45H2,1-6H3,(H,46,61)(H,47,64)(H,48,60)(H,49,59)(H,50,62)(H,51,63)(H,57,58)(H,66,67)/t24-,25+,28-,29-,30-,31-,32-,35-,36-/m0/s1

InChI Key

BLEZYVGGTWZGPY-YDTVLPSFSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NCC(=O)N2CCCC2C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)N

1. Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3

Roger G Deeley, Susan P C Cole, Curtis J Oleschuk Am J Physiol Gastrointest Liver Physiol . 2003 Feb;284(2):G280-9. doi: 10.1152/ajpgi.00331.2002.

Multidrug resistance protein 3 (MRP3) is an ATP-dependent transporter of 17beta-estradiol 17beta(d-glucuronide) (E(2)17betaG), leukotriene C(4) (LTC(4)), methotrexate, and the bile salts taurocholate and glycocholate. In the present study, the role of a highly conserved Trp residue at position 1242 on MRP3 transport function was examined by expressing wild-type MRP3 and Ala-, Cys-, Phe-, Tyr-, and Pro-substituted mutants in human embryonic kidney 293T cells. Four MRP3-Trp(1242) mutants showed significantly increased E(2)17betaG uptake, whereas transport by the Pro mutant was undetectable. Similarly, the Pro mutant did not transport LTC(4). By comparison, LTC(4) transport by the Ala, Cys, Phe, and Tyr mutants was reduced by approximately 35%. The Ala, Cys, Phe, and Tyr mutants all showed greatly reduced methotrexate and leucovorin transport, except the Tyr mutant, which transported leucovorin at levels comparable with wild-type MRP3. In contrast, the MRP3-Trp(1242) substitutions did not significantly affect taurocholate transport or taurocholate and glycocholate inhibition of E(2)17betaG uptake. Thus Trp(1242) substitutions markedly alter the substrate specificity of MRP3 but leave bile salt binding and transport intact.