1. Glutaurine enhances the depressed NK cell activity of tumor patients
P Gergely, K Nékám, I Láng, L Feuer, A Szigeti, G Petrányi Immunol Commun . 1983 Oct;12(5):519-27. doi: 10.3109/08820138309051969.
The effect of glutaurine, a newly discovered parathyroid substance, on human NK cell activity and on lymphocyte markers was studied. Both in vivo and in vitro treatment with glutaurine markedly enhanced the depressed natural lymphocytotoxicity of tumor patients without influencing their lymphocyte subpopulations. On the other hand it had no effect on the NK cell activity of healthy lymphocytes and of tumor patients' lymphocytes with originally "normal" NK activity. The NK-enhancing effect of glutaurine could not be explained by augmentation of the number of potential effector cells. It is suggested that glutaurine increases the originally low spontaneous killer activity of tumor patients' lymphocytes through an indirect regulatory mechanism.
2. Effect of glutaurine on the pineal gland of the rat
G Csaba, F Sudár, B Madarász, L Feuer Acta Morphol Acad Sci Hung . 1980;28(3):233-42.
Glutaurine (gamma-L-glutamyl-taurine), the recently discovered hormone of the parathyroid enhances the aggregation and subsequent degeneration of mitochondria in the pinealocyte processes of the rat pineal gland. It also stimulates autophagy, probably through its general lysosome activating effect.
3. Inhibition of the formation of protein storage granules by glutaurine in the larval fat body cells of Mamestra brassicae (Insecta, Lepidoptera)
M Sass, L Feuer, L G Kömüves, J Kovács Acta Biol Hung . 1986;37(3-4):249-57.
Correlative changes in the protein contents of haemolymph and fat body and the accumulation of protein storage granules in the fat body cells of Mamestra brassicae were investigated during the last larval stage in normally developing larvae and following administration of glutaurine (1 X 10(-4) mg/g body weight). The protein content of the haemolymph of untreated larvae increased up to the 4th day of the stage, declined during days 5 and 6, and increased again before pupation. In the glutaurine-treated larvae the amount of proteins in the haemolymph was as high as in the controls during the first four days but continued to rise up to the end of the stage. The protein content of the fat body started to increase from the 3rd day and heavy accumulation of protein storage granules in the cells of fat body was observed on the 5th and following days. The protein content of the fat body of glutaurine-treated larvae remained at a low level and the protein storage granules were absent in the cells. The inhibition of the selective uptake of haemolymphatic storage proteins by fat body following glutaurine treatment is suggested.
