(Gly22)-Amyloid β-Protein (1-42)

(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxyethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

Amyloid β-Protein (1-42) Arctic Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gly-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-glycyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine

White Lyophilized Powder

≥95%

DAEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVVIA

Store at -20°C

Soluble in DMSO

InChI=1S/C200H307N55O58S/c1-28-105(20)162(192(305)218-90-148(265)226-128(69-97(4)5)178(291)236-127(64-68-314-27)176(289)248-156(99(8)9)190(303)216-85-144(261)212-86-150(267)247-158(101(12)13)195(308)252-161(104(18)19)196(309)255-163(106(21)29-2)197(310)225-111(26)199(312)313)254-198(311)164(107(22)30-3)253-167(280)109(24)222-145(262)87-214-169(282)121(51-40-42-65-201)231-185(298)137(79-143(205)260)242-189(302)141(93-257)229-149(266)91-217-191(304)157(100(10)11)249-188(301)138(80-154(274)275)228-146(263)88-213-165(278)108(23)224-177(290)131(71-112-45-34-31-35-46-112)239-181(294)133(73-114-49-38-33-39-50-114)244-193(306)160(103(16)17)251-187(300)129(70-98(6)7)237-171(284)122(52-41-43-66-202)232-173(286)124(58-61-142(204)259)234-182(295)134(75-116-82-208-94-219-116)241-184(297)136(77-118-84-210-96-221-118)245-194(307)159(102(14)15)250-175(288)126(60-63-152(270)271)235-179(292)130(74-115-54-56-119(258)57-55-115)227-147(264)89-215-170(283)140(92-256)246-186(299)139(81-155(276)277)243-183(296)135(76-117-83-209-95-220-117)240-172(285)123(53-44-67-211-200(206)207)233-180(293)132(72-113-47-36-32-37-48-113)238-174(287)125(59-62-151(268)269)230-166(279)110(25)223-168(281)120(203)78-153(272)273/h31-39,45-50,54-57,82-84,94-111,120-141,156-164,256-258H,28-30,40-44,51-53,58-81,85-93,201-203H2,1-27H3,(H2,204,259)(H2,205,260)(H,208,219)(H,209,220)(H,210,221)(H,212,261)(H,213,278)(H,214,282)(H,215,283)(H,216,303)(H,217,304)(H,218,305)(H,222,262)(H,223,281)(H,224,290)(H,225,310)(H,226,265)(H,227,264)(H,228,263)(H,229,266)(H,230,279)(H,231,298)(H,232,286)(H,233,293)(H,234,295)(H,235,292)(H,236,291)(H,237,284)(H,238,287)(H,239,294)(H,240,285)(H,241,297)(H,242,302)(H,243,296)(H,244,306)(H,245,307)(H,246,299)(H,247,267)(H,248,289)(H,249,301)(H,250,288)(H,251,300)(H,252,308)(H,253,280)(H,254,311)(H,255,309)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,312,313)(H4,206,207,211)/t105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-,162-,163-,164-/m0/s1

ACBSAQUKMPSPRO-NALNEICTSA-N

CCC(C)C(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)N)NC(=O)C(CC3=CN=CN3)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC6=CN=CN6)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N