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H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH is an internally quenched substrate for calpain-1 (µ-calpain) with optimal cleavage motifs flanking the scissile bond. The turnover rate of the enzyme to hydrolysis of this FRET substrate based on the PLFAER amino acid sequence is more than 18 times higher than that of EVYGMM derived from the natural substrate α-spectrin cleavage site.

Category

Others

Catalog number

BAT-014553

CAS number

1914987-47-5

Molecular Formula

C72H97N17O16S

Molecular Weight

1488.71

Specification

IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[5-(2-aminoethylamino)naphthalen-1-yl]sulfonylamino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-[[4-[[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]hexanoic acid

Synonyms

N-({5-[(2-Aminoethyl)amino]-1-naphthyl}sulfonyl)-L-α-glutamyl-L-prolyl-L-leucyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-arginyl-N6-(4-{[4-(dimethylamino)phenyl]diazenyl}benzoyl)-L-lysine

Appearance

Red Powder

Purity

≥95%

Density

1.4±0.1 g/cm3

Sequence

E(EDANS)-PLFAER-K(DABCYL)

Storage

Store at -20°C

Solubility

Soluble in Acetic Acid, DMSO, Water

InChI

InChI=1S/C72H97N17O16S/c1-43(2)41-57(84-69(100)59-22-14-40-89(59)70(101)55(33-35-62(92)93)87-106(104,105)60-23-12-17-50-51(60)18-11-20-52(50)76-39-36-73)68(99)83-58(42-45-15-7-6-8-16-45)67(98)79-44(3)63(94)80-54(32-34-61(90)91)66(97)81-53(21-13-38-78-72(74)75)65(96)82-56(71(102)103)19-9-10-37-77-64(95)46-24-26-47(27-25-46)85-86-48-28-30-49(31-29-48)88(4)5/h6-8,11-12,15-18,20,23-31,43-44,53-59,76,87H,9-10,13-14,19,21-22,32-42,73H2,1-5H3,(H,77,95)(H,79,98)(H,80,94)(H,81,97)(H,82,96)(H,83,99)(H,84,100)(H,90,91)(H,92,93)(H,102,103)(H4,74,75,78)/t44-,53-,54-,55-,56-,57-,58-,59-/m0/s1

InChI Key

ZBTCIQPDYVIPOU-DAPRKCRDSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCNC(=O)C2=CC=C(C=C2)N=NC3=CC=C(C=C3)N(C)C)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCC(=O)O)NS(=O)(=O)C5=CC=CC6=C5C=CC=C6NCCN