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Hexapeptide-33

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Hexapeptide-33 is a biologically active peptide that has been reported for use in cosmetics due to its multifaceted benefits for the skin. It is known to stimulate blood vessel formation and is developed under the trade name W3 peptide by Novacell Technology. This peptide consists of the amino acids arginine, leucine, lysine, phenylalanine, serine, and tyrosine. It has been proven to have skin whitening effects, contribute to wound healing, reduce wrinkles, promote cell migration, and stimulate collagen synthesis while inhibiting melanin synthesis. Hexapeptide-33 also acts as an antioxidant, directly inhibiting tyrosinase during melanin biosynthesis, which reduces the synthesis of melanin and inhibits the activity of tyrosinase in melanoma B16 cells. It is used in skincare for its whitening properties, induced angiogenesis in human endothelial cells, and accelerated wound healing. It also promotes hair growth and eyelash growth.

Category

Cosmetic Peptides

Catalog number

BAT-016728

CAS number

1192135-40-2

Molecular Formula

C39H60N10O9

Molecular Weight

812.96

Specification

IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid

Synonyms

H-Ser-Phe-Lys-Leu-Arg-Tyr-OH; H-SFKLRY-OH; SFKLRY; L-Seryl-L-phenylalanyl-L-lysyl-L-leucyl-L-arginyl-L-tyrosine

Purity

≥95%

Density

1.37±0.1 g/cm3

Sequence

Ser-Phe-Lys-Leu-Arg-Tyr

Storage

Store at -20 °C

InChI

InChI=1S/C39H60N10O9/c1-23(2)19-30(36(55)46-29(12-8-18-44-39(42)43)35(54)49-32(38(57)58)21-25-13-15-26(51)16-14-25)48-34(53)28(11-6-7-17-40)45-37(56)31(47-33(52)27(41)22-50)20-24-9-4-3-5-10-24/h3-5,9-10,13-16,23,27-32,50-51H,6-8,11-12,17-22,40-41H2,1-2H3,(H,45,56)(H,46,55)(H,47,52)(H,48,53)(H,49,54)(H,57,58)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1

InChI Key

KMHVZJAZIOYFIB-JNRWAQIZSA-N

Canonical SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)N