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Hippuryl-L-lysine

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Hippuryl-L-lysine is a substrate for carboxypeptidase B and carboxypeptidase N.

Category

Others

Catalog number

BAT-015460

CAS number

740-63-6

Molecular Formula

C15H21N3O4

Molecular Weight

307.34

Specification
Reference Reading

IUPAC Name

(2S)-6-amino-2-[(2-benzamidoacetyl)amino]hexanoic acid

Synonyms

Hippuryl-Lys-OH; Bz-GK-OH; L-Lysine,N-benzoylglycyl-; (S)-6-Amino-2-(2-benzamidoacetamido)hexanoic acid

Density

1.229 g/cm3

Boiling Point

662.3°C at 760 mmHg

Sequence

Bz-Gly-Lys-OH

InChI

InChI=1S/C15H21N3O4/c16-9-5-4-8-12(15(21)22)18-13(19)10-17-14(20)11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,16H2,(H,17,20)(H,18,19)(H,21,22)/t12-/m0/s1

InChI Key

LRCZLURYHGISRZ-LBPRGKRZSA-N

Canonical SMILES

C1=CC=C(C=C1)C(=O)NCC(=O)NC(CCCCN)C(=O)O

3. Rapid assay of human plasma carboxypeptidase N by high-performance liquid chromatographic separation of hippuryl-lysine and its product

F Marceau, A Drumheller, M Gendreau, A Lussier, S St-Pierre J Chromatogr. 1983 Aug 26;266:173-7. doi: 10.1016/s0021-9673(01)90890-8.

A rapid and sensitive method for measuring carboxypeptidase N (CPN) activity in human plasma is described. The procedure is based on the hydrolysis of a high-specificity/low-affinity substrate, hippuryl-L-lysine, to its products hippuric acid and lysine. The substrate and product are separated quantitatively by high-performance liquid chromatography in less than 10 min following a minimal sample preparation time. The advantages of this method over previous ones are discussed and data are presented demonstrating the reliability of this method for the routine clinical determination of CPN activity.