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Histone H3.3 (84-98) is a truncated fragment of Histone H3.3. Histone 3 family 3 (H3F3) histones (H3.3) mark active genes, maintain epigenetic memory, and maintain heterochromatin and telomeric integrity.
2. Chromatin and histones: binding of tritiated actinomycin D to heterochromatin in mealy bugs
L Berlowitz, D Pallotta, C H Sibley Science. 1969 Jun 27;164(3887):1527-9. doi: 10.1126/science.164.3887.1527.
The degree of actinomycin D binding to DNA in chromatin is dependent upon the state of repression of chromatin. Living cells bind three times more tritiated actinomycin to euchromatin than to genetically inactive heterochromatin. Extraction of histone results in a general increase in tritiated actinomycin binding and in a ratio of the uptake in heterochromatin to that in euchromatin approaching unity.
