Melanin Concentrating Hormone, salmon acetate
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Melanin Concentrating Hormone, salmon acetate

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Melanin Concentrating Hormone, salmon acetate is a 19-amino acid neuropeptide, originally found in the pituitary gland of teleost fish, that regulates food intake, energy balance, sleep status and the cardiovascular system. MCH is a ligand for orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

Category
Peptide Inhibitors
Catalog number
BAT-016397
Molecular Formula
C91H143N27O26S4
Molecular Weight
2159.55
Melanin Concentrating Hormone, salmon acetate
IUPAC Name
acetic acid;(4S)-4-[[(2S)-2-[[(3S,6S,9S,12S,18S,21S,24R,29R,32S)-24-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3,12-bis(3-carbamimidamidopropyl)-6-[(4-hydroxyphenyl)methyl]-21-(2-methylsulfanylethyl)-2,5,8,11,14,17,20,23,31-nonaoxo-9,18-di(propan-2-yl)-26,27-dithia-1,4,7,10,13,16,19,22,30-nonazabicyclo[30.3.0]pentatriacontane-29-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-[[(1S)-1-carboxy-2-methylpropyl]amino]-5-oxopentanoic acid
Synonyms
MCH (salmon) acetate; L-Valine, L-α-aspartyl-L-threonyl-L-methionyl-L-arginyl-L-cysteinyl-L-methionyl-L-valylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-arginyl-L-prolyl-L-cysteinyl-L-tryptophyl-L-α-glutamyl-, cyclic (5→14)-disulfide acetate; Melanin-concentrating hormone (Oncorhynchus keta) acetate; Melanin-concentrating hormone (Carassius auratus) acetate; Melanin-concentrating hormone (Oncorhynchus keta reduced), cyclic (5→14)-disulfide acetate; Salmon melanin-concentrating hormone acetate; H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH.CH3CO2H (Disulfide bridge: Cys5-Cys14); L-alpha-aspartyl-L-threonyl-L-methionyl-L-arginyl-L-cysteinyl-L-methionyl-L-valyl-glycyl-L-arginyl-L-valyl-L-tyrosyl-L-arginyl-L-prolyl-L-cysteinyl-L-tryptophyl-L-alpha-glutamyl-L-valine (5->14)-disulfide
Related CAS
87218-84-6 (free base)
Purity
≥95%
Sequence
DTMRCMVGRVYRPCWEV.CH3CO2H (Disulfide bridge: Cys5-Cys14)
Storage
Store at -20°C
InChI
InChI=1S/C89H139N27O24S4.C2H4O2/c1-43(2)67-82(135)101-40-64(119)102-53(18-12-30-97-87(91)92)74(127)113-68(44(3)4)83(136)109-59(36-47-22-24-49(118)25-23-47)77(130)107-58(20-14-32-99-89(95)96)85(138)116-33-15-21-63(116)81(134)111-62(80(133)108-60(37-48-39-100-52-17-11-10-16-50(48)52)78(131)104-55(26-27-65(120)121)75(128)114-69(45(5)6)86(139)140)42-144-143-41-61(79(132)105-57(29-35-142-9)76(129)112-67)110-72(125)54(19-13-31-98-88(93)94)103-73(126)56(28-34-141-8)106-84(137)70(46(7)117)115-71(124)51(90)38-66(122)123;1-2(3)4/h10-11,16-17,22-25,39,43-46,51,53-63,67-70,100,117-118H,12-15,18-21,26-38,40-42,90H2,1-9H3,(H,101,135)(H,102,119)(H,103,126)(H,104,131)(H,105,132)(H,106,137)(H,107,130)(H,108,133)(H,109,136)(H,110,125)(H,111,134)(H,112,129)(H,113,127)(H,114,128)(H,115,124)(H,120,121)(H,122,123)(H,139,140)(H4,91,92,97)(H4,93,94,98)(H4,95,96,99);1H3,(H,3,4)/t46-,51+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63?,67+,68+,69+,70+;/m1./s1
InChI Key
LDPJYEWTMZYDIM-JJEVKUGUSA-N
Canonical SMILES
CC(C)C1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)O)CCCNC(=N)N)CC5=CC=C(C=C5)O)C(C)C)CCCNC(=N)N.CC(=O)O
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