N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate
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N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate

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Category
CBZ-Amino Acids
Catalog number
BAT-005972
CAS number
210471-09-3
Molecular Formula
C16H23NO7
Molecular Weight
341.36
N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate
IUPAC Name
(2R)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid;hydrate
Synonyms
Z-D-Asp(OtBu)-OH H2O
InChI
InChI=1S/C16H21NO6.H2O/c1-16(2,3)23-13(18)9-12(14(19)20)17-15(21)22-10-11-7-5-4-6-8-11;/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20);1H2/t12-;/m1./s1
InChI Key
UWDOQNWFLPMMLQ-UTONKHPSSA-N
Canonical SMILES
CC(C)(C)OC(=O)CC(C(=O)O)NC(=O)OCC1=CC=CC=C1.O

N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate is a chemical reagent used in peptide synthesis and organic chemistry research. Here are some key applications of N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate:

Peptide Synthesis: N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate is used as a protected amino acid in the synthesis of peptides. The protective groups help prevent undesired side reactions during peptide bond formation. This ensures the efficient assembly of complex peptides and proteins in the laboratory.

Drug Development: This compound plays a crucial role in the synthesis of peptide-based pharmaceuticals. By protecting specific amino acids, researchers can design and develop peptide drugs with enhanced stability and efficacy. This method is vital for creating medications targeting specific proteins and signaling pathways.

Bioconjugation: In bioconjugation techniques, N-α-Carbobenzoxy-D-aspartic acid β-t-butyl ester hydrate is used to modify biomolecules. The compound’s protective groups allow for selective reactions, making it possible to attach peptides to drugs, imaging agents, or other molecules. This is essential in developing targeted therapeutic and diagnostic tools.

Protein Engineering: This reagent is also valuable in protein engineering to create modified proteins for research and industrial applications. By incorporating protected amino acids, scientists can introduce specific functional groups or improve protein properties. This strategy aids in the study of protein structure and function, as well as in the production of recombinant proteins.

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