N-α-Carbobenzoxy-L-homocitrulline
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N-α-Carbobenzoxy-L-homocitrulline

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Category
CBZ-Amino Acids
Catalog number
BAT-006918
CAS number
57533-91-2
Molecular Formula
C15H21N3O5
Molecular Weight
323.35
N-α-Carbobenzoxy-L-homocitrulline
IUPAC Name
(2S)-6-(carbamoylamino)-2-(phenylmethoxycarbonylamino)hexanoic acid
Synonyms
Z-homoCit-OH; Z-Lys(Carbamoyl)-OH; N-α-Carbobenzoxy-N-ε-carbamoyl-L-lysine
Storage
Store at -20 °C
InChI
InChI=1S/C15H21N3O5/c16-14(21)17-9-5-4-8-12(13(19)20)18-15(22)23-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10H2,(H,18,22)(H,19,20)(H3,16,17,21)/t12-/m0/s1
InChI Key
GDAQVXISDUMUJG-LBPRGKRZSA-N
Canonical SMILES
C1=CC=C(C=C1)COC(=O)NC(CCCCNC(=O)N)C(=O)O

N-α-Carbobenzoxy-L-homocitrulline, a synthetically derived amino acid derivative, finds diverse applications in biochemical and pharmaceutical realms.

Peptide Synthesis: Acting as a crucial building block in peptide and protein synthesis, N-α-Carbobenzoxy-L-homocitrulline enables the creation of peptides with tailored structural and functional characteristics. Researchers intricately weave this derivative into peptide chains, crafting molecules with precise attributes essential for drug design, biochemical exploration, and the advancement of synthetic biology.

Drug Development: Within the domain of pharmaceutical inquiry, N-α-Carbobenzoxy-L-homocitrulline serves as a linchpin, unraveling the intricacies of enzyme inhibition and protein-protein interactions. As a substrate analog, it sheds light on enzyme mechanisms and unveils potential inhibitors, crucial for the development of novel therapeutic agents targeting diverse maladies, steering the course of medical progress.

Biomedical Research: Delving into protein modifications like post-translational modifications (PTMs), N-α-Carbobenzoxy-L-homocitrulline stands as a valuable tool in scientific inquiry. By integrating this derivative, scientists unveil the impacts of specific modifications on protein functionality and interactions. These studies offer profound insights into the orchestration of cellular processes and pave the way for innovative therapeutic interventions, enriching the landscape of biomedicine.

Structural Biology: In the intricate world of structural biology, N-α-Carbobenzoxy-L-homocitrulline plays a pivotal role in aiding the crystallization and structural examination of proteins. By stabilizing protein structures, it facilitates the acquisition of high-resolution crystallographic insights. This utilization is indispensable for comprehending the intricate molecular frameworks of proteins and tailoring drugs that precisely target these architectural formations, driving advances at the interface of biology and medicine.

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