Inquiry Basket
A building block for the synthesis of thioethyl-modified peptides.
N,N’-Di(t-butoxycarbonyl)cystamine, also known as Boc-cystamine, is a valuable reagent in synthetic and medicinal chemistry. Here are some key applications of N,N’-Di(t-butoxycarbonyl)cystamine:
Peptide Synthesis: Boc-cystamine is commonly used in peptide synthesis as a protecting group for cysteine residues. By temporarily masking the thiol group of cysteine, it prevents unwanted side reactions during peptide chain assembly. This facilitates the efficient synthesis of cysteine-containing peptides with high purity and yield.
Drug Development: In medicinal chemistry, Boc-cystamine is used to create prodrugs with improved stability and bioavailability. By conjugating active drugs to Boc-cystamine, researchers can enhance the pharmacokinetic properties of therapeutic compounds. Once in the body, the Boc group is removed, releasing the active drug at the target site.
Bioconjugation: Boc-cystamine is employed in bioconjugation techniques to create stable linkages between biomolecules. Its disulfide linkage allows for the controlled release of conjugated molecules under reductive conditions. This is useful in the development of targeted drug delivery systems and diagnostic agents.
Chemical Biology: In chemical biology research, Boc-cystamine is used to study redox-sensitive processes and protein folding. By incorporating Boc-cystamine into proteins, researchers can investigate how disulfide bond formation influences protein structure and function. This aids in understanding disease mechanisms related to oxidative stress and misfolded proteins.
