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Novokinin acetate

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Novokinin acetate is an angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Novokinin exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4 interaction.

Category

Peptide Inhibitors

Catalog number

BAT-016306

CAS number

2803405-27-6

Molecular Formula

C41H65N11O9

Molecular Weight

856.02

Specification

IUPAC Name

acetic acid;(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoic acid

Synonyms

H-Arg-Pro-Leu-Lys-Pro-Trp-OH.CH3CO2H; L-arginyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-tryptophan acetic acid; Acetic acid, compd. with (L-arginyl-yl-L-leucyl-yl-L-lysyl-yl-L-prolyl-yl-L-prolyl-yl)-L-Tryptophan (1:1)

Related CAS

358738-77-9 (free base)

Purity

≥95%

Sequence

RPLKPW.CH3CO2H

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C39H61N11O7.C2H4O2/c1-23(2)20-29(47-34(52)31-14-8-18-49(31)36(54)26(41)11-7-17-44-39(42)43)33(51)46-28(13-5-6-16-40)37(55)50-19-9-15-32(50)35(53)48-30(38(56)57)21-24-22-45-27-12-4-3-10-25(24)27;1-2(3)4/h3-4,10,12,22-23,26,28-32,45H,5-9,11,13-21,40-41H2,1-2H3,(H,46,51)(H,47,52)(H,48,53)(H,56,57)(H4,42,43,44);1H3,(H,3,4)/t26-,28-,29-,30-,31-,32-;/m0./s1

InChI Key

XUGBIBJUJPZXFG-UNHDVCAASA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N.CC(=O)O