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NRC-13

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NRC-13 is an antimicrobial peptide found in American plaice AP3, Hippoglossoides platessoides Fabricius. It has antimicrobial activity against gram-negative bacteria, gram-positive bacteria and Fungi.

Category
Functional Peptides
Catalog number
BAT-011771
Molecular Formula
C125H211N35O28
Molecular Weight
2652.28
IUPAC Name
(4S)-4-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Synonyms
H-Gly-Trp-Arg-Thr-Leu-Leu-Lys-Lys-Ala-Glu-Val-Lys-Thr-Val-Gly-Lys-Leu-Ala-Leu-Lys-His-Tyr-Leu-NH2; glycyl-L-tryptophyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-alpha-glutamyl-L-valyl-L-lysyl-L-threonyl-L-valyl-glycyl-L-lysyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-histidyl-L-tyrosyl-L-leucinamide; (4S,7S,10S,13S,16S,19S,22S,25S,31S,34S,37S,40S,43S)-10-((1H-imidazol-5-yl)methyl)-43-((2S,5S,8S,11S,14S,17S,20S,23S)-23-((1H-indol-3-yl)methyl)-26-amino-5,8-bis(4-aminobutyl)-20-(3-guanidinopropyl)-17-((R)-1-hydroxyethyl)-11,14-diisobutyl-2-methyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazahexacosanamido)-13,25,37-tris(4-aminobutyl)-4-carbamoyl-7-(4-hydroxybenzyl)-34-((R)-1-hydroxyethyl)-16,22-diisobutyl-31,40-diisopropyl-2,19-dimethyl-6,9,12,15,18,21,24,27,30,33,36,39,42-tridecaoxo-5,8,11,14,17,20,23,26,29,32,35,38,41-tridecaazahexatetracontan-46-oic acid
Appearance
Powder
Purity
≥97%
Sequence
GWRTLLKKAEVKTVGKLALKHYL-NH2
Storage
Store at -20°C
InChI
InChI=1S/C125H211N35O28/c1-65(2)52-89(104(132)168)150-118(182)94(57-76-40-42-79(163)43-41-76)154-120(184)96(59-78-62-135-64-139-78)155-110(174)85(37-24-29-49-129)147-115(179)91(54-67(5)6)151-106(170)73(16)141-114(178)90(53-66(3)4)152-108(172)82(34-21-26-46-126)142-98(165)63-138-121(185)100(70(11)12)158-124(188)103(75(18)162)160-111(175)86(38-25-30-50-130)149-122(186)101(71(13)14)157-113(177)88(44-45-99(166)167)144-105(169)72(15)140-107(171)83(35-22-27-47-127)145-109(173)84(36-23-28-48-128)146-116(180)92(55-68(7)8)153-117(181)93(56-69(9)10)156-123(187)102(74(17)161)159-112(176)87(39-31-51-136-125(133)134)148-119(183)95(143-97(164)60-131)58-77-61-137-81-33-20-19-32-80(77)81/h19-20,32-33,40-43,61-62,64-75,82-96,100-103,137,161-163H,21-31,34-39,44-60,63,126-131H2,1-18H3,(H2,132,168)(H,135,139)(H,138,185)(H,140,171)(H,141,178)(H,142,165)(H,143,164)(H,144,169)(H,145,173)(H,146,180)(H,147,179)(H,148,183)(H,149,186)(H,150,182)(H,151,170)(H,152,172)(H,153,181)(H,154,184)(H,155,174)(H,156,187)(H,157,177)(H,158,188)(H,159,176)(H,160,175)(H,166,167)(H4,133,134,136)/t72-,73-,74+,75+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,100-,101-,102-,103-/m0/s1
InChI Key
ZXDNPDYNERPMPQ-DTYYDIKASA-N
Canonical SMILES
CC(C)CC(C(=O)N)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CC2=CN=CN2)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)CN
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