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NRWC

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

NRWC is an antimicrobial peptide found in Bacillus subtilis, and has antibacterial activity.

Category
Functional Peptides
Catalog number
BAT-011773
Molecular Formula
C46H62N14O15S
Molecular Weight
1083.14
IUPAC Name
L-asparaginyl-L-arginyl-L-tryptophyl-L-cysteinyl-L-phenylalanyl-L-alanylglycyl-L-aspartyl-L-aspartic acid
Synonyms
Asn-Arg-Trp-Cys-Phe-Ala-Gly-Asp-Asp; NRWC (Bacteriocin)
Purity
>98%
Sequence
NRWCFAGDD
1. Quality of life two years after severe trauma: a single-centre evaluation
Sigune Kaske, Rolf Lefering, Heiko Trentzsch, Arne Driessen, Bertil Bouillon, Marc Maegele, Christian Probst Injury. 2014 Oct;45 Suppl 3:S100-5. doi: 10.1016/j.injury.2014.08.028.
Introduction: Trauma related injuries are a main cause for long-lasting morbidity and disability especially in younger patients with their productive years ahead. On a routine basis, we assessed health related quality of life two years after trauma of severely injured patients at our level-I trauma centre via posted survey. Patients and methods: The posted survey included (1) POLO-Chart questionnaire with European Quality of Life (EuroQoL), Short Form Health Survey-36 (SF 36) and the recently developed and validated Trauma Outcome Profile (TOP) combined with (2) single centre data according to TraumaRegister DGU(®) data sets including trauma mechanism, injuries and initial treatment. Inclusion criteria were severely injured patients ≥ 18 years, treated between 2008 and 2010. Exclusion criteria were death, cognitive impairment, lack of German language and denial of participation. Results: 129 datasets were eligible for analysis reflecting a typical trauma collective with mean age 44 years, predominantly male (67%), mean ISS 22 and 98% blunt trauma. Two years after trauma, 62% of the patients reported of relevant remaining pain and 64% of severe functional deficit in at least one body region. Sixty-four percent of the patients suffered from decreased overall quality of life (EuroQoL≤0.8). Additionally, all domains of SF-36 were impaired compared to an age and gender adjusted cohort of healthy individuals, especially domains of pain and activity of daily living. These impairments were associated with decreased 'social functioning' and 'emotional role functioning'. TOP results confirmed these findings: Quality of life was decreased in almost every dimension. TOP additionally identified sequels especially in domains of "Mental Functioning" and impairments in psychological recovery including post-traumatic stress disorder, depression and anxiety. Socioeconomic impairments were frequent including further hospitalisations (62%), duration of inability to work ≥ 6 month (54%), financial disadvantages (45%) and work loss (26%). Conclusion: Our results demonstrate that multiple trauma patients two years after injury suffer from impairments including persisting pain, functional deficits, mental and socioeconomic deficits. The 'Trauma Outcome Profile' instrument seems a proper tool to discover impairments in trauma patients early on and guide proper rehabilitation resources to the best of the patient.
2. Factors associated with reduced longer-term capacity to work in patients after polytrauma: a Swiss trauma center experience
Thomas Gross, Corinna Attenberger, Rolf W Huegli, Felix Amsler J Am Coll Surg. 2010 Jul;211(1):81-91. doi: 10.1016/j.jamcollsurg.2010.02.042. Epub 2010 May 15.
Background: Knowledge of the factors associated with longer-term reduced capacity to work (RCW) is lacking in patients after polytrauma. Study design: We studied a prospectively collected cohort of polytrauma survivors (n = 115; age 39.5 +/- 20.6 years [mean +/- SD]; 98% blunt trauma; Injury Severity Score [ISS] 27.5 +/- 8.2) at a university trauma center. Uni- and multivariable analyses of patient, trauma, and treatment characteristics as well as parameters of self-reported functional outcomes were studied to determine their association with a reduced capacity to work (RCW) at least 2 years after injury. Results: Postinjury quality of life was worse compared with preinjury status in univariate analysis (eg, Euro Quality of Life Group Visual Analogue Scale [EQ VAS] 66.2 +/- 24.4 vs 89.7 +/- 14.7; p = <0.001). In 53% of patients (n = 61), an RCW was found and functional outcomes were significantly lower than those in non-RCW patients (p < 0.001). Lower educational status (odds ratio [OR] 0.25; 95% CI 0.07 to 0.92; p = 0.036), higher ISS (OR 1.12; 95% CI 1.02 to 1.22; p = 0.017), less time in the emergency room (OR 0.92; 95% CI 0.86 to 0.97; p = 0.005), higher mean nurse labor per day and patient (OR 1.01; 95% CI 1.000 to 1.004; p = 0.033), and a reduced Nottingham Health Profile value (OR 1.10; 95% CI 1.06 to 1.15; p < 0.001) were associated with an RCW in the multiple logistic regression model (proportion of variance explained: 0.74). Conclusions: In this cohort of patients surviving polytrauma, approximately 50% of patients sustained longer-term RCW. Several characteristics, such as level of education or trauma severity, showed an independent association with patients' capacity to work, which was significantly associated with patients' self-rated scorings of well-being.
3. Prevalence and incidence of longer term pain in survivors of polytrauma
Thomas Gross, Felix Amsler Surgery. 2011 Nov;150(5):985-95. doi: 10.1016/j.surg.2011.04.003. Epub 2011 Jun 15.
Background: Little is known about the longer term status of pain or the factors associated with pain-related outcome in patients after polytrauma. The current study evaluated the prevalence and severity of pain at least 2 years after injury compared with preinjury status using several pain scores in a Swiss cohort of survivors of blunt polytrauma. Methods: Pearson correlation testing was used for the comparison of different measures of pain. Uni and multivariate analyses of patient, trauma, and treatment characteristics, as well as parameters of self-reported, health-related quality of life and functional outcome, were undertaken to determine associations with pain after polytrauma. Results: Depending on the measure used, 46% to 85% of polytrauma survivors indicated the presence of pain at longer term follow-up. Both the prevalence and the severity of pain were increased compared with the preinjury status (P < .001) and varied importantly depending on scoring. The Trauma Outcome Profile was the most sensitive pain measure and showed the greatest correlation with objective, longer term outcomes (R = .5). Pain measured by the SF-36 was found to have the best internal criterion validity among the scores investigated (R = .6-.8). Patients' longer term pain status had greater associations with health-related quality-of-life scores (R = .6-.8) than with capacity to work or income (R = .4-.5). Conclusion: Our study shows a high rate of longer term pain in survivors of polytrauma and important differences in the type and sensitivity of the standard pain measures investigated. Given the potential impact of these findings, international guidelines for the assessment of pain in polytraumatized patients are needed.
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