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Oligopeptide-68

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Oligopeptide-68 is a synthetic skin-brightening peptide that is derived from a protein called tyrosinase. It is known for its ability to inhibit melanin synthesis and reduce pigmentation in the skin. This peptide works by mimicking the binding of TGF-β to cell surface receptors, which leads to the inhibition of MITF intramolecular channels, thereby reducing induced and hereditary pigmentation. It is effective in reducing the formation of melanin-related molecules such as MITF, TRP-1, TRP-2, and tyrosinase, as well as inhibiting the activity of tyrosinase and melanin synthesis. Oligopeptide-68 can improve skin brightness, reduce the appearance of dark spots, and provide a more even skin tone. It is also recognized for its anti-inflammatory and antioxidant properties, which help it play a role in whitening and anti-aging skin care products.

Category

Cosmetic Peptides

Catalog number

BAT-016723

CAS number

1206525-47-4

Molecular Formula

C62H91N17O21

Molecular Weight

1410.49

Specification

IUPAC Name

(2S)-5-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoic acid

Synonyms

Glycyl-L-arginylglycyl-L-α-aspartyl-L-tyrosyl-L-isoleucyl-L-tryptophyl-L-seryl-L-leucyl-L-α-aspartyl-L-threonyl-L-glutamine; Oligopeptide 68; H-Gly-Arg-Gly-Asp-Tyr-Ile-Trp-Ser-Leu-Asp-Thr-Gln-OH; H-GRGDYIWSLDTQ-OH; Gly-Arg-Gly-Asp-Tyr-Ile-Trp-Ser-Leu-Asp-Thr-Gln

Related CAS

2763584-75-2 (acetate salt)

Appearance

White to off-white solid

Purity

≥95%

Density

1.52±0.1 g/cm3

Sequence

GRGDYIWSLDTQ

Storage

Store at -20 °C

Solubility

Soluble in DMSO

InChI

InChI=1S/C62H91N17O21/c1-6-30(4)50(78-56(94)40(21-32-13-15-34(82)16-14-32)74-55(93)42(23-48(86)87)71-47(85)27-69-52(90)37(70-46(84)25-63)12-9-19-67-62(65)66)59(97)76-41(22-33-26-68-36-11-8-7-10-35(33)36)54(92)77-44(28-80)58(96)73-39(20-29(2)3)53(91)75-43(24-49(88)89)57(95)79-51(31(5)81)60(98)72-38(61(99)100)17-18-45(64)83/h7-8,10-11,13-16,26,29-31,37-44,50-51,68,80-82H,6,9,12,17-25,27-28,63H2,1-5H3,(H2,64,83)(H,69,90)(H,70,84)(H,71,85)(H,72,98)(H,73,96)(H,74,93)(H,75,91)(H,76,97)(H,77,92)(H,78,94)(H,79,95)(H,86,87)(H,88,89)(H,99,100)(H4,65,66,67)/t30-,31+,37-,38-,39-,40-,41-,42-,43-,44-,50-,51-/m0/s1

InChI Key

HPPYJXKCLMBZCN-ZDQKBINTSA-N

Canonical SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CN