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P21

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

When administered peripherally to normal adult mice, the pentamer P21 significantly enhanced cognition, increased proliferation and neuronal differentiation of adult hippocampal progenitors and promoted the expression of synaptic vesicle proteins, synaptophysin and synapsin I. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus.

Category

Peptide Inhibitors

Catalog number

BAT-016518

Molecular Formula

C27H42N6O8

Molecular Weight

578.66

Specification

IUPAC Name

(S)-3-acetamido-4-((2-((2-(((S)-1-(((1s,3S,5R,7S)-3-carbamoyladamantan-1-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-2-oxoethyl)amino)-4-oxobutanoic acid

Synonyms

Ac-Asp-Gly-Gly-Leu-adamantane-Gly-NH2; N-Acetyl-L-α-aspartylglycylglycyl-N-[(1s,3S,5R,7S)-3-(aminocarbonyl)tricyclo[3.3.1.13,7]dec-1-yl]-L-leucinamide

Purity

≥95%

Sequence

Ac-DGGL-adamantane-G-NH2

InChI

InChI=1S/C27H42N6O8/c1-14(2)4-18(24(40)33-27-9-16-5-17(10-27)8-26(7-16,13-27)25(28)41)32-21(36)12-29-20(35)11-30-23(39)19(6-22(37)38)31-15(3)34/h14,16-19H,4-13H2,1-3H3,(H2,28,41)(H,29,35)(H,30,39)(H,31,34)(H,32,36)(H,33,40)(H,37,38)/t16-,17+,18-,19-,26+,27-/m0/s1

InChI Key

LUJZBZPLIRWWGJ-DJZHFBFESA-N

Canonical SMILES

O=C(O)CC(NC(=O)C)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC12CC3CC(C1)CC(C(=O)N)(C3)C2)CC(C)C