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P22 N (14-30)

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The peptide sequence is found in residues 14 to 30 of P22 N. P22 N is a transcriptional antiterminator that binds to N-utilization (NUT) sites on viral transcripts. P22 N modifies RNA polymerase activity by creating a termination-resistant form of the RNA polymerase complex that is able to continue transcribing the viral transcript.

Category
Functional Peptides
Catalog number
BAT-013330
Molecular Formula
C90H164N40O24
Molecular Weight
2190.55
IUPAC Name
(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-oxopentanoic acid
Synonyms
H-Asn-Ala-Lys-Thr-Arg-Arg-His-Glu-Arg-Arg-Arg-Lys-Leu-Ala-Ile-Glu-Arg-OH; P22 N-(14-30); L-asparagyl-L-alanyl-L-lysyl-L-threonyl-L-arginyl-L-arginyl-L-histidyl-L-alpha-glutamyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-isoleucyl-L-alpha-glutamyl-L-arginine
Appearance
White Powder
Purity
≥95%
Sequence
NAKTRRHERRRKLAIER
Storage
Store at -20°C
Solubility
Soluble in pure water. Avoid repeated freezing and thawing.
InChI
InChI=1S/C90H164N40O24/c1-8-45(4)66(82(151)125-59(28-30-65(135)136)78(147)126-60(84(153)154)26-18-38-113-90(105)106)129-69(138)47(6)116-80(149)61(39-44(2)3)127-75(144)51(19-9-11-31-91)118-71(140)53(21-13-33-108-85(95)96)119-72(141)54(22-14-34-109-86(97)98)120-73(142)55(23-15-35-110-87(99)100)122-77(146)58(27-29-64(133)134)123-81(150)62(40-49-42-107-43-114-49)128-76(145)56(24-16-36-111-88(101)102)121-74(143)57(25-17-37-112-89(103)104)124-83(152)67(48(7)131)130-79(148)52(20-10-12-32-92)117-68(137)46(5)115-70(139)50(93)41-63(94)132/h42-48,50-62,66-67,131H,8-41,91-93H2,1-7H3,(H2,94,132)(H,107,114)(H,115,139)(H,116,149)(H,117,137)(H,118,140)(H,119,141)(H,120,142)(H,121,143)(H,122,146)(H,123,150)(H,124,152)(H,125,151)(H,126,147)(H,127,144)(H,128,145)(H,129,138)(H,130,148)(H,133,134)(H,135,136)(H,153,154)(H4,95,96,108)(H4,97,98,109)(H4,99,100,110)(H4,101,102,111)(H4,103,104,112)(H4,105,106,113)/t45-,46-,47-,48+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,66-,67-/m0/s1
InChI Key
ULRCXLKGKGLLAH-YFOIFZSCSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)O)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC1=CN=CN1)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CC(=O)N)N
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