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Pentapeptide-3 diacetate is a synthetic peptide with the sequence Gly-Pro-Arg-Pro-Ala-NH2.2CH3CO2H. It is recognized for its Botox-like effects, providing a smoothing and anti-aging action on the skin. This peptide acts as a competitive antagonist of nicotinic acetylcholine receptors, blocking the membrane's receptors and leaving a curare-like effect. By mimicking the action of curare at the post-synaptic membrane, Pentapeptide-3 blocks signal transfer from neurons to muscles, functioning as a neuromuscular blocking agent similar to Botox but used in topical applications. This results in the relaxation of facial muscles and a reduction in muscle contractions, which helps to smooth expression lines and deep wrinkles. It can regenerate the upper layer of the skin by stimulating the production of collagen.
