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Pomalidomide-PEG2-C2-NH2

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Pomalidomide-PEG2-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Category

Peptide Synthesis Reagents

Catalog number

BAT-006302

CAS number

2093416-32-9

Molecular Formula

C19H24N4O6

Molecular Weight

404.42

Specification

IUPAC Name

4-[2-[2-(2-aminoethoxy)ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Synonyms

Thalidomide-NH-PEG2-NH2; 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-({2-[2-(2-Aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-; 4-({2-[2-(2-aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; Thalidomide-NH-PEG2-C2-NH2

Related CAS

2376139-55-6 (dihydrochloride) 2245697-87-2 (monohydrochloride) 2097509-36-7 (TFA salt)

Appearance

White to Off-white Solid

Purity

≥95%

Density

1.4±0.1 g/cm3

Boiling Point

675.9±55.0°C at 760 mmHg

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)