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[pThr3]-CDK5 Substrate

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

[pThr3]-CDK5 Substrate is an effective substrate of Phospho-Thr3CDK5. It is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. It is phosphorylated by CDK5 with a Km value of 6 µM.

Category

Others

Catalog number

BAT-009151

CAS number

1670273-47-8

Molecular Formula

C53H100N15O15P

Molecular Weight

1218.43

Specification

IUPAC Name

(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-6-amino-2-[[(2S)-pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-phosphonooxybutanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-methylpentanoic acid

Synonyms

H-Pro-Lys-Thr(PO3H2)-Pro-Lys-Lys-Ala-Lys-Lys-Leu-OH; L-prolyl-L-lysyl-O3-phosphono-L-threonyl-L-prolyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-leucine; Pro-Lys-pTHR-Pro-Lys-Lys-Ala-Lys-Lys-Leu

Appearance

Solid

Purity

≥95%

Density

1.257±0.06 g/cm3 (Predicted)

Sequence

PK-pTHR-PKKAKKL

Storage

Store at -20°C

Solubility

Soluble in Water

InChI

InChI=1S/C53H100N15O15P/c1-32(2)31-41(53(78)79)66-49(74)38(19-7-12-26-56)64-47(72)37(18-6-11-25-55)61-44(69)33(3)60-46(71)36(17-5-10-24-54)63-48(73)39(20-8-13-27-57)65-51(76)42-23-16-30-68(42)52(77)43(34(4)83-84(80,81)82)67-50(75)40(21-9-14-28-58)62-45(70)35-22-15-29-59-35/h32-43,59H,5-31,54-58H2,1-4H3,(H,60,71)(H,61,69)(H,62,70)(H,63,73)(H,64,72)(H,65,76)(H,66,74)(H,67,75)(H,78,79)(H2,80,81,82)/t33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1

InChI Key

DOSIYTHCWIDLCR-BJSZDZKQSA-N

Canonical SMILES

CC(C)CC(C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(C(C)OP(=O)(O)O)NC(=O)C(CCCCN)NC(=O)C2CCCN2