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Ranatuerin-9

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Ranatuerin-9 is an antimicrobial peptide found in Rana catesbeiana (Lithobates catesbeianus, North American bull frog), and has antibacterial activity against gram-positive bacterium S.aureus (MIC=130 µM). It shows no detectable hemolytic activity towards human erythrocytes.

Category
Functional Peptides
Catalog number
BAT-011446
CAS number
215715-59-6
Molecular Formula
C83H129N15O18
Molecular Weight
1625.00
IUPAC Name
(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoic acid
Synonyms
H-Phe-Leu-Phe-Pro-Leu-Ile-Thr-Ser-Phe-Leu-Ser-Lys-Val-Leu-OH; L-phenylalanyl-L-leucyl-L-phenylalanyl-L-prolyl-L-leucyl-L-isoleucyl-L-threonyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-lysyl-L-valyl-L-leucine
Appearance
Lyophilized Powder
Purity
≥96%
Density
1.2±0.1 g/cm3
Boiling Point
1749.0±65.0°C at 760 mmHg
Sequence
FLFPLITSFLSKVL
Storage
Store at -20°C
InChI
InChI=1S/C83H129N15O18/c1-14-51(12)68(96-75(107)60(39-48(6)7)90-78(110)66-34-26-36-98(66)82(114)62(43-55-31-22-17-23-32-55)91-72(104)58(37-46(2)3)87-70(102)56(85)41-53-27-18-15-19-28-53)80(112)97-69(52(13)101)81(113)94-65(45-100)77(109)89-61(42-54-29-20-16-21-30-54)74(106)88-59(38-47(4)5)73(105)93-64(44-99)76(108)86-57(33-24-25-35-84)71(103)95-67(50(10)11)79(111)92-63(83(115)116)40-49(8)9/h15-23,27-32,46-52,56-69,99-101H,14,24-26,33-45,84-85H2,1-13H3,(H,86,108)(H,87,102)(H,88,106)(H,89,109)(H,90,110)(H,91,104)(H,92,111)(H,93,105)(H,94,113)(H,95,103)(H,96,107)(H,97,112)(H,115,116)/t51-,52+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-/m0/s1
InChI Key
KIWPHCXILYOBPU-UTXAJUJOSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC(C)C)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)N
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