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TAT-NSF700 Fusion Peptide

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

It is a N-Ethyl-maleimide-sensitive factor (NSF) inhibitor fusion polypeptide, which is fused from the 11 amino acid cell permeable HIV transactivation regulatory protein (TAT) domain to the 22 amino acid NSF domain. TAT-NSF700 inhibits thrombin-induced exocytosis of endothelial cells in a dose-responsive manner.

Category

Functional Peptides

Catalog number

BAT-013290

Molecular Formula

C188H318N62O45

Molecular Weight

4167.00

Specification

IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoic acid

Synonyms

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Leu-Leu-Asp-Tyr-Val-Pro-Ile-Gly-Pro-Arg-Phe-Ser-Asn-Leu-Val-Leu-Gln-Ala-Leu-Leu-Val-Leu-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-glycyl-glycyl-glycyl-L-leucyl-L-leucyl-L-alpha-aspartyl-L-tyrosyl-L-valyl-L-prolyl-L-isoleucyl-glycyl-L-prolyl-L-arginyl-L-phenylalanyl-L-seryl-L-asparagyl-L-leucyl-L-valyl-L-leucyl-L-glutaminyl-L-alanyl-L-leucyl-L-leucyl-L-valyl-L-leucine

Appearance

Lyophilized Solid

Purity

≥95%

Sequence

YGRKKRRQRRRGGGLLDYVPIGPRFSNLVLQALLVL

Storage

Store at -20°C

Solubility

Freely soluble in water. Avoid repeated freezing and thawing.

InChI

InChI=1S/C188H318N62O45/c1-24-105(22)150(177(290)220-93-145(261)249-75-39-52-136(249)175(288)233-121(51-38-74-215-188(207)208)162(275)238-130(85-107-41-26-25-27-42-107)168(281)244-135(94-251)174(287)240-132(87-140(194)256)169(282)237-129(82-100(12)13)172(285)245-147(102(16)17)178(291)242-127(80-98(8)9)165(278)232-122(62-64-138(192)254)154(267)221-106(23)151(264)234-125(78-96(4)5)166(279)236-128(81-99(10)11)171(284)246-148(103(18)19)179(292)243-134(181(294)295)83-101(14)15)248-176(289)137-53-40-76-250(137)180(293)149(104(20)21)247-173(286)131(86-109-56-60-111(253)61-57-109)239-170(283)133(88-146(262)263)241-167(280)126(79-97(6)7)235-164(277)124(77-95(2)3)223-143(259)91-217-141(257)89-216-142(258)90-219-153(266)113(45-32-68-209-182(195)196)224-158(271)117(47-34-70-211-184(199)200)228-160(273)119(49-36-72-213-186(203)204)230-163(276)123(63-65-139(193)255)231-161(274)120(50-37-73-214-187(205)206)229-159(272)118(48-35-71-212-185(201)202)227-157(270)116(44-29-31-67-190)226-156(269)115(43-28-30-66-189)225-155(268)114(46-33-69-210-183(197)198)222-144(260)92-218-152(265)112(191)84-108-54-58-110(252)59-55-108/h25-27,41-42,54-61,95-106,112-137,147-150,251-253H,24,28-40,43-53,62-94,189-191H2,1-23H3,(H2,192,254)(H2,193,255)(H2,194,256)(H,216,258)(H,217,257)(H,218,265)(H,219,266)(H,220,290)(H,221,267)(H,222,260)(H,223,259)(H,224,271)(H,225,268)(H,226,269)(H,227,270)(H,228,273)(H,229,272)(H,230,276)(H,231,274)(H,232,278)(H,233,288)(H,234,264)(H,235,277)(H,236,279)(H,237,282)(H,238,275)(H,239,283)(H,240,287)(H,241,280)(H,242,291)(H,243,292)(H,244,281)(H,245,285)(H,246,284)(H,247,286)(H,248,289)(H,262,263)(H,294,295)(H4,195,196,209)(H4,197,198,210)(H4,199,200,211)(H4,201,202,212)(H4,203,204,213)(H4,205,206,214)(H4,207,208,215)/t105-,106-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,147-,148-,149-,150-/m0/s1

InChI Key

WOMQUENYMPHYGZ-DBFSEMHMSA-N

Canonical SMILES

CCC(C)C(C(=O)NCC(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CC5=CC=C(C=C5)O)N