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TFLLR-NH2 2TFA

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TFLLR-NH2 2TFA, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM.

Category

Peptide Inhibitors

Catalog number

BAT-016420

Molecular Formula

C31H53N9O6.2C2HF3O2

Molecular Weight

875.87

Specification

IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide;2,2,2-trifluoroacetic acid

Synonyms

H-Thr-Phe-Leu-Leu-Arg-NH2.2TFA; TFLLR-NH2.2TFA; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid; PAR-1-AP trifluoroacetate; Protease-activated receptor-1-activating peptide trifluoroacetate

Related CAS

197794-83-5 (free base) 1313730-19-6 (mono(TFA salt))

Purity

≥95%

Sequence

Thr-Phe-Leu-Leu-Arg-NH2.2TFA

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C31H53N9O6.2C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;2*3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);2*(H,6,7)/t19-,21+,22+,23+,24+,25+;;/m1../s1

InChI Key

IHIZYLUTWSYLIE-NLCLUUQHSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)O)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O