Thymopoietin II (32-35)
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Thymopoietin II (32-35)

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Category
Others
Catalog number
BAT-010712
CAS number
85466-18-8
Molecular Formula
C21H40N8O7
Molecular Weight
516.59
Thymopoietin II (32-35)
IUPAC Name
(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
Synonyms
n-(n-(n(sup2)-l-arginyl-l-lysyl)-l-alpha-aspartyl)-l-valin; n-(n-(n(sup2)-l-arginyl-l-lysyl)-l-alpha-aspartyl)-l-valine; rgh0206; H-ARG-LYS-ASP-VAL-OH; ARG-LYS-ASP-VAL; TP-4; TP II (32-35); THYMOPOIETIN II (32-35)
Purity
95%
Density
1.45g/cm3
Sequence
H-Arg-Lys-Asp-Val-OH
Storage
Store at 2-8°C
InChI
InChI=1S/C21H40N8O7/c1-11(2)16(20(35)36)29-19(34)14(10-15(30)31)28-18(33)13(7-3-4-8-22)27-17(32)12(23)6-5-9-26-21(24)25/h11-14,16H,3-10,22-23H2,1-2H3,(H,27,32)(H,28,33)(H,29,34)(H,30,31)(H,35,36)(H4,24,25,26)/t12-,13-,14-,16-/m0/s1
InChI Key
COIXXKVZEXZCLU-YXWQFLTLSA-N
Canonical SMILES
CC(C)C(C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N
1.Immunoregulating peptides II. In vitro effects of TP5 analogs on E-rosette formation and cell division.
Denes L1, Szende B, Ember J, Major J, Szporny L, Hajos G, Nyeki O, Schon I, Lapis K, Kisfaludy L. Immunopharmacol Immunotoxicol. 1987;9(1):1-18.
The effects of seventeen synthetic analogs of thymopentin (TP-5) have been studied in the active and azathioprine-inhibited E-rosette tests. Thymopentin was gradually shortened from the C terminus to peptides and single amino acids. Thymopoietin 32-34 (Arg-Lys-Asp-RGH-0205-TP-3) (II) and thymopoietin 32-35 (Arg-Lys-Asp-Val-RGH-0206-TP-4) (I) were the most active peptides. Dipeptide Arg-Lys produced significant stimulatory effect on azathioprine (ED75) inhibited E-receptor. Treatment of azathioprine (ED75)-inhibited E-rosette forming cells (ERFC) with arginine or especially lysine increased the number of ERFC. Some of TP-4 analogs decreased further the number of ERFC decreased by azathioprine ED30. These "suppressive" peptides as well as TP-3 caused a partial arrest of K 562 cell proliferation up to 96 hours. Results suggest that TP-5 is not the smallest active fragment of thymopoietins, since peptides (TP-3 and TP-4) exhibit similar or higher T-cell membrane activation on E-receptor.
2.Therapeutic possibilities of thymopoietin fragments (TP3 and TP4) based on experimental animal models.
Dénes L1, Szende B, Hajós G, Szporny L, Lapis K. Drugs Exp Clin Res. 1987;13(5):279-87.
The effects of thymic hormones are focused on the induction of T-cell subpopulations and restoration of the reactivity of an impaired immune system. TP3 and TP4 (corresponding to thymopoietin 32-34 and 32-35) exert a thymic hormone substitution effect. These peptides elicit dissimilar quantitative and qualitative effects. The aim of the present experiments was to investigate: (a) the effect of thymopoietin fragments in mice with unbalanced immune systems caused by experimental manipulation; and (b) the ratio of target cells after treatment. The distribution of Thy1, Lyt1, Lyt2 positivity was determined in a direct complement mediated cytotoxicity test. Autoantibody production was measured by Coombs' test. A count of Lewis Lung Tumour (LLT) metastases was made after two weeks of inoculation. Groups of mice were thymectomized and/or injected with cyclophosphamide (CY) (240 mg/kg) 96 h before tumour cell inoculation. The number of LLT metastases was decreased by treatment with peptides (TP3 = 72, TP4 = 97, TP5[thymopoietin 32-36] = 83.
3.Transport and metabolic pathway of thymocartin (TP4) in excised bovine nasal mucosa.
Lang S1, Langguth P, Oschmann R, Traving B, Merkle HP. J Pharm Pharmacol. 1996 Nov;48(11):1190-6.
Thymocartin (TP4, Arg-Lys-Asp-Val) is the 32-35 fragment of the naturally occurring thymic factor (thymopoietin). Here studies on the nasal transport and metabolism of TP4 were performed. Freshly excised bovine nasal mucosa was taken as a model membrane. For permeation studies typical donor-receiver experiments (side-by-side) and finite-dose experiments with small volumes of highly concentrated solutions were carried out. The metabolic pathway of TP4 in nasal mucosa was found to occur according to a typical aminopeptidase cleavage pattern, stepwise forming Lys-Asp-Val and Asp-Val. TP4 metabolism experiments under reflection kinetics showed a saturation profile above 0.5 mumol mL-1. A non-linear kinetic model consisting of three steps in sequence was sufficient to describe the kinetics: for the first step saturable Michaelis-Meat kinetics, and for the second and the third step first-order kinetics were assured. The model was capable of simultaneously fitting the data for the full range of initial concentrations from 0.
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